Position β57 of I-A g7 controls early anti-insulin responses in NOD mice, linking an MHC susceptibility allele to type 1 diabetes onset-Reference-Cited by-同舟云学术

Position β57 of I-A g7 controls early anti-insulin responses in NOD mice, linking an MHC susceptibility allele to type 1 diabetes onset

Published:2019-08-02 Issue:38 Volume:4 Page:
ISSN:2470-9468
Container-title:Science Immunology
language:en
Short-container-title:Sci. Immunol.

Author:

Gioia Louis¹^ORCID,Holt Marie²,Costanzo Anne²^ORCID,Sharma Siddhartha²^ORCID,Abe Brian²^ORCID,Kain Lisa²,Nakayama Maki³^ORCID,Wan Xiaoxiao⁴,Su Andrew¹^ORCID,Mathews Clayton⁵^ORCID,Chen Yi-Guang⁶,Unanue Emil⁴,Teyton Luc²^ORCID

Affiliation:

1. Department of Integrative Structural and Computational Biology, Scripps Research Institute, La Jolla, CA 92037, USA.

2. Department of Immunology and Microbiology, Scripps Research Institute, La Jolla, CA 92037, USA.

3. Department of Pediatrics and Department of Immunology and Microbiology, Barbara Davis Center for Diabetes, University of Colorado School of Medicine, Denver, CO 80045, USA.

4. Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO 63110, USA.

5. Department of Pediatrics, Medical College of Wisconsin, Milwaukee, WI 53226, USA.

6. University of Florida College of Medicine, Gainesville, FL 32611, USA.

Abstract

Onset of type 1 diabetes in NOD mice is triggered by the recognition of I-A g7 insulin peptide complexes by islet CD4 + T cells.

Funder

National Institutes of Health

Publisher

American Association for the Advancement of Science (AAAS)

Subject

General Medicine,Immunology

Reference60 articles.

1. HL-A, IMMUNE-RESPONSE GENES, AND DISEASE

2. HL-A ANTIGENS AND DIABETES MELLITUS

3. Understanding type 1 diabetes through genetics: advances and prospects

4. Etiology of Type 1 Diabetes

5. Extreme genetic risk for type 1A diabetes

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