Interfacial actin protrusions mechanically enhance killing by cytotoxic T cells-Reference-Cited by-同舟云学术

Interfacial actin protrusions mechanically enhance killing by cytotoxic T cells

Published:2019-03-22 Issue:33 Volume:4 Page:
ISSN:2470-9468
Container-title:Science Immunology
language:en
Short-container-title:Sci. Immunol.

Author:

Tamzalit Fella¹^ORCID,Wang Mitchell S.²^ORCID,Jin Weiyang³^ORCID,Tello-Lafoz Maria¹^ORCID,Boyko Vitaly⁴,Heddleston John M.⁵^ORCID,Black Charles T.⁶^ORCID,Kam Lance C.³^ORCID,Huse Morgan¹^ORCID

Affiliation:

1. Immunology Program, Memorial Sloan Kettering Cancer Center, New York, NY, USA.

2. Pharmacology Graduate Program, Weill Cornell Medical College, New York, NY, USA.

3. Department of Biomedical Engineering, Columbia University, New York, NY, USA.

4. Molecular Cytology Core Facility, Memorial Sloan Kettering Cancer Center, New York, NY, USA.

5. Advanced Imaging Center, Janelia Research Campus, Howard Hughes Medical Institute, Ashburn, VA, USA.

6. Center for Functional Nanomaterials, Brookhaven National Laboratory, Upton, NY, USA.

Abstract

Cytotoxic T cells use actin-rich protrusions at the immunological synapse to enhance perforin-mediated target cell killing.

Funder

National Science Foundation

National Cancer Institute

National Institute of Allergy and Infectious Diseases

Cancer Research Institute

Ramon Areces Foundation

Leukemia and Lymphoma Society

Publisher

American Association for the Advancement of Science (AAAS)

Subject

General Medicine,Immunology

Reference61 articles.

1. Cell:cell interactions in the immune system

2. Cytotoxic immunological synapses

3. Secretory Mechanisms in Cell-Mediated Cytotoxicity

4. Perforin: A Key Pore-Forming Protein for Immune Control of Viruses and Cancer

5. How Do Cytotoxic Lymphocytes Kill Cancer Cells?

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