Production of BMP4 by endothelial cells is crucial for endogenous thymic regeneration-Reference-Cited by-同舟云学术

Production of BMP4 by endothelial cells is crucial for endogenous thymic regeneration

Published:2018-01-26 Issue:19 Volume:3 Page:
ISSN:2470-9468
Container-title:Science Immunology
language:en
Short-container-title:Sci. Immunol.

Author:

Wertheimer Tobias¹²^ORCID,Velardi Enrico¹^ORCID,Tsai Jennifer¹³^ORCID,Cooper Kirsten³^ORCID,Xiao Shiyun⁴^ORCID,Kloss Christopher C.⁵⁶^ORCID,Ottmüller Katja J.⁷^ORCID,Mokhtari Zeinab⁷,Brede Christian⁷,deRoos Paul³,Kinsella Sinéad³,Palikuqi Brisa⁵^ORCID,Ginsberg Michael⁸,Young Lauren F.¹^ORCID,Kreines Fabiana¹^ORCID,Lieberman Sophia R.¹,Lazrak Amina¹,Guo Peipei⁵,Malard Florent¹^ORCID,Smith Odette M.¹,Shono Yusuke¹^ORCID,Jenq Robert R.⁹^ORCID,Hanash Alan M.⁹^ORCID,Nolan Daniel J.⁸^ORCID,Butler Jason M.⁵,Beilhack Andreas⁷^ORCID,Manley Nancy R.⁴,Rafii Shahin⁵,Dudakov Jarrod A.³¹⁰^ORCID,van den Brink Marcel R. M.¹⁹^ORCID

Affiliation:

1. Immunology Program, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.

2. Division of Hematology and Oncology, Department of Medicine, Freiburg University Medical Center, Albert-Ludwigs-University, 79106 Freiburg, Germany.

3. Program in Immunology, Clinical Research Division, and Immunotherapy Integrated Research Center, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA.

4. Department of Genetics, University of Georgia, Athens, GA 30602, USA.

5. Department of Genetic Medicine and Ansary Stem Cell Institute, Weill Cornell Medical College, New York, NY 10021, USA.

6. Center for Cell Engineering, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.

7. Department of Medicine II, Würzburg University Hospital, Interdisciplinary Center for Clinical Research (IZKF), and Graduate School of Life Sciences, University of Würzburg, Würzburg, Germany.

8. Angiocrine Bioscience, San Diego, CA 92130, USA.

9. Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.

10. Department of Immunology, University of Washington, Seattle, WA 98109, USA.

Abstract

BMP4 produced by endothelial cells promotes thymic regeneration after acute damage by activating FOXN1 and its downstream targets.

Funder

National Heart, Lung, and Blood Institute

National Cancer Institute

National Institute of Allergy and Infectious Diseases

American Society of Hematology

Publisher

American Association for the Advancement of Science (AAAS)