Single-cell analysis of human B cell maturation predicts how antibody class switching shapes selection dynamics-Reference-Cited by-同舟云学术

Single-cell analysis of human B cell maturation predicts how antibody class switching shapes selection dynamics

Author:

King Hamish W.¹²^ORCID,Orban Nara³,Riches John C.⁴⁵^ORCID,Clear Andrew J.⁴^ORCID,Warnes Gary⁶^ORCID,Teichmann Sarah A.²⁷^ORCID,James Louisa K.¹^ORCID

Affiliation:

1. Centre for Immunobiology, Blizard Institute, Queen Mary University of London, London E1 2AT, UK.

2. Wellcome Sanger Institute, Wellcome Genome Campus, Hinxton, Cambridge CB10 1SA, UK.

3. Barts Health Ear, Nose and Throat Service, Royal London Hospital, London E1 1BB, UK.

4. Centre for Haemato-Oncology, Barts Cancer Institute, Queen Mary University of London, London EC1M 6BQ, UK.

5. Francis Crick Institute, London NW1 1AT, UK.

6. Flow Cytometry Core Facility, Blizard Institute, Queen Mary University of London, London E1 2AT, UK.

7. Theory of Condensed Matter, Cavendish Laboratory, Department of Physics, University of Cambridge, Cambridge CB3 0EH, UK.

Abstract

Integrated single-cell transcriptomic and BCR analyses reveal how antibody class switching influences human B cell fate and function.

Funder

Wellcome

Publisher

American Association for the Advancement of Science (AAAS)

Subject

General Medicine,Immunology

Reference77 articles.

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