AIRE expression controls the peripheral selection of autoreactive B cells

Author:

Sng Joel1ORCID,Ayoglu Burcu2ORCID,Chen Jeff W.1ORCID,Schickel Jean-Nicolas1,Ferre Elise M. N.3ORCID,Glauzy Salomé1,Romberg Neil45ORCID,Hoenig Manfred6ORCID,Cunningham-Rundles Charlotte7ORCID,Utz Paul J.28ORCID,Lionakis Michail S.3ORCID,Meffre Eric1ORCID

Affiliation:

1. Department of Immunobiology, Yale University School of Medicine, New Haven, CT 06511, USA.

2. School of Medicine, Division of Immunology and Rheumatology, Stanford University, Stanford, CA 94305, USA.

3. Laboratory of Clinical Immunology and Microbiology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD USA.

4. Division of Immunology and Allergy, Children’s Hospital of Philadelphia, Philadelphia, PA, USA.

5. Department of Pediatrics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.

6. Department of Pediatrics, University Medical Centre Ulm, Ulm, Germany.

7. Division of Allergy and Immunology, Department of Medicine, Icahn School of Medicine, Mount Sinai, New York, NY 10029, USA.

8. Institute for Immunity, Transplantation, and Infection (ITI), Stanford University, Stanford, CA 94305, USA.

Abstract

T cells and their proper AIRE-dependent selection prevent the accumulation of autoreactive naïve B cells in the periphery.

Funder

National Institutes of Health

National Institute of Allergy and Infectious Diseases

National Center for Research Resources

Jeffrey Modell Foundation

Donald E. and Delia B. Baxter Foundation

Knut och Alice Wallenbergs Stiftelse

Henry Gustav Floren Trust

Stanford’s Autoimmunity Center of Excellence

Agency for Science, Technology and Research

Publisher

American Association for the Advancement of Science (AAAS)

Subject

General Medicine,Immunology

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