Intrinsic properties of human germinal center B cells set antigen affinity thresholds-Reference-Cited by-同舟云学术

Intrinsic properties of human germinal center B cells set antigen affinity thresholds

Published:2018-11-30 Issue:29 Volume:3 Page:
ISSN:2470-9468
Container-title:Science Immunology
language:en
Short-container-title:Sci. Immunol.

Author:

Kwak Kihyuck¹^ORCID,Quizon Nicolas¹^ORCID,Sohn Haewon¹,Saniee Avva¹,Manzella-Lapeira Javier¹,Holla Prasida¹^ORCID,Brzostowski Joseph¹^ORCID,Lu Jinghua¹,Xie HengYi²^ORCID,Xu Chenguang²^ORCID,Spillane Katelyn M.³⁴⁵^ORCID,Tolar Pavel⁴⁵^ORCID,Pierce Susan K.¹^ORCID

Affiliation:

1. Laboratory of Immunogenetics, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rockville, MD 20852, USA.

2. MOE Key Laboratory of Protein Sciences, Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, School of Life Sciences, Institute for Immunology, Tsinghua University, Beijing, China.

3. Department of Physics, King’s College London, London WC2R 2LS, UK.

4. Immune Receptor Activation Laboratory, Francis Crick Institute, London NW1 1AT, UK.

5. Division of Immunology and Inflammation, Imperial College London, London SW7 2AZ, UK.

Abstract

Human germinal center B cells are intrinsically designed for optimal affinity-based selection.

Funder

NIH Office of the Director

Publisher

American Association for the Advancement of Science (AAAS)

Subject

General Medicine,Immunology

Reference45 articles.