Resistance to PD1 blockade in the absence of metalloprotease-mediated LAG3 shedding

Author:

Andrews Lawrence P.123ORCID,Somasundaram Ashwin1234ORCID,Moskovitz Jessica M.123ORCID,Szymczak-Workman Andrea L.1ORCID,Liu Chang123ORCID,Cillo Anthony R.123ORCID,Lin Huang5ORCID,Normolle Daniel P.5ORCID,Moynihan Kelly D.67ORCID,Taniuchi Ichiro8ORCID,Irvine Darrell J.679ORCID,Kirkwood John M.34ORCID,Lipson Evan J.10ORCID,Ferris Robert L.2311,Bruno Tullia C.123,Workman Creg J.123ORCID,Vignali Dario A. A.123ORCID

Affiliation:

1. Department of Immunology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.

2. Tumor Microenvironment Center, UPMC Hillman Cancer Center, Pittsburgh, PA, USA.

3. Cancer Immunology and Immunotherapy Program, UPMC Hillman Cancer Center, Pittsburgh, PA, USA.

4. Department of Medicine, Division of Hematology/Oncology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.

5. Department of Biostatistics, University of Pittsburgh School of Public Health, Pittsburgh, PA, USA.

6. Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA, USA.

7. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA, USA.

8. RIKEN Center for Integrative Medical Sciences, Yokohama City, Kanagawa, Japan.

9. Howard Hughes Medical Institute, Chevy Chase, MD, USA.

10. Department of Oncology, Sidney Kimmel Comprehensive Cancer Center, and Bloomberg-Kimmel Institute for Cancer Immunotherapy, Johns Hopkins University School of Medicine, Baltimore, MD, USA.

11. Department of Otolaryngology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.

Abstract

LAG3 shedding from conventional CD4 + T cells drives responsiveness to anti-PD1 immunotherapy (see the related Focus by Seidel and Bengsch ).

Funder

NIH Office of the Director

Publisher

American Association for the Advancement of Science (AAAS)

Subject

General Medicine,Immunology

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