PD-1 blockade and vaccination provide therapeutic benefit against SIV by inducing broad and functional CD8 + T cells in lymphoid tissue-Reference-Cited by-同舟云学术

PD-1 blockade and vaccination provide therapeutic benefit against SIV by inducing broad and functional CD8 + T cells in lymphoid tissue

Published:2021-09-24 Issue:63 Volume:6 Page:
ISSN:2470-9468
Container-title:Science Immunology
language:en
Short-container-title:Sci. Immunol.

Author:

Rahman Sheikh Abdul¹²^ORCID,Yagnik Bhrugu¹²^ORCID,Bally Alexander P.¹²^ORCID,Morrow Kristen N.¹²^ORCID,Wang Shelly¹^ORCID,Vanderford Thomas H.¹,Freeman Gordon J.³⁴^ORCID,Ahmed Rafi¹²^ORCID,Amara Rama Rao¹²^ORCID

Affiliation:

1. Division of Microbiology and Immunology, Emory Vaccine Center, Yerkes National Primate Research Center, Emory University, Atlanta, GA, USA.

2. Department of Microbiology and Immunology, Emory School of Medicine, Emory University, Atlanta, GA, USA.

3. Department of Medical Oncology and Cancer Vaccine Center, Dana-Farber Cancer Institute, Boston, MA, USA.

4. Harvard Medical School, Boston, MA, USA.

Abstract

PD-1 blockade combined with vaccination induced anti-SIV immunity and reduced SIV viral reservoirs in lymphoid tissue.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

General Medicine,Immunology

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