Humanization of T cell–mediated immunity in mice-Reference-Cited by-同舟云学术

Humanization of T cell–mediated immunity in mice

Published:2021-12-24 Issue:66 Volume:6 Page:
ISSN:2470-9468
Container-title:Science Immunology
language:en
Short-container-title:Sci. Immunol.

Author:

Moore Michael J.¹^ORCID,Zhong Maggie¹^ORCID,Hansen Johanna¹^ORCID,Gartner Hans¹,Grant Craig¹,Huang Mei¹,Harris Faith M.¹^ORCID,Tu Naxin¹,Bowerman Natalie A.¹,Edelmann Kurt H.¹^ORCID,Barry Thomas¹^ORCID,Herbin Olivier¹^ORCID,Tay Chin-Siean¹,DiLillo David J.¹^ORCID,Decker Corinne E.¹,Levenkova Natasha¹^ORCID,Shevchuk James¹^ORCID,Dhanik Ankur¹^ORCID,Meagher Karoline A.¹^ORCID,Karr Amanda¹^ORCID,Roos Jan¹,Lee Wen-yi¹^ORCID,Suh David¹,Eckersdorff Mark¹^ORCID,Meagher T. Craig¹^ORCID,Koss Matthew¹,Esau Lakeisha¹,Sleeman Matthew A.¹^ORCID,Babb Robert¹,Chen Gang¹,Kyratsous Christos A.¹^ORCID,Poueymirou William T.¹^ORCID,McWhirter John R.¹,Voronina Vera A.¹^ORCID,Guo Chunguang¹,Gurer Cagan¹,Yancopoulos George D.¹,Murphy Andrew J.¹^ORCID,Macdonald Lynn E.¹^ORCID

Affiliation:

1. Regeneron Pharmaceuticals, 777 Old Saw Mill River Rd, Tarrytown, NY 10591, USA.

Abstract

Knock-in mice with humanized TCR, MHC, and co-receptor genes enable therapeutic human TCR discovery and functional assessment in mice.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

General Medicine,Immunology

Reference35 articles.

1. Adoptive cell transfer as personalized immunotherapy for human cancer

2. Results of Clinical Trials with the Administration of Interleukin 2 and Adoptive Immunotherapy with Activated Cells in Patients with Cancer

3. Use of Tumor-Infiltrating Lymphocytes and Interleukin-2 in the Immunotherapy of Patients with Metastatic Melanoma