Islet-reactive CD8 + T cell frequencies in the pancreas, but not in blood, distinguish type 1 diabetic patients from healthy donors

Author:

Culina Slobodan123ORCID,Lalanne Ana Ines123ORCID,Afonso Georgia123,Cerosaletti Karen4ORCID,Pinto Sheena5,Sebastiani Guido6ORCID,Kuranda Klaudia123ORCID,Nigi Laura6ORCID,Eugster Anne7ORCID,Østerbye Thomas8ORCID,Maugein Alicia123ORCID,McLaren James E.9,Ladell Kristin9,Larger Etienne12310ORCID,Beressi Jean-Paul11ORCID,Lissina Anna1213,Appay Victor1213,Davidson Howard W.14ORCID,Buus Søren8,Price David A.915,Kuhn Matthias16ORCID,Bonifacio Ezio7ORCID,Battaglia Manuela17ORCID,Caillat-Zucman Sophie18,Dotta Francesco6,Scharfmann Raphael123,Kyewski Bruno5,Mallone Roberto12310ORCID,Carel Jean-Claude,Tubiana-Rufi Nadia,Martinerie Laetitia,Poidvin Amélie,JacqzAigrain Evelyne,Corvez Laurence,Berruer Véronique,Gautier Jean-François,Baz Baz,Haddadi Nassima,Andreelli Fabrizio,Amouyal Chloé,Jaqueminet Sophie,Bourron Olivier,Dasque Eric,Hartemann Agnès,Lemoine-Yazigi Amal,Dubois-Laforgue Danièle,Travert Florence,Feron Marilyne,Rolland Patrice,Vignali Valérie,Marre Michel,Chanson Philippe,Briet Claire,Guillausseau Pierre-Jean,Ait-Bachir Leila,Collet Carole,Beziaud Frédéric,Desforges-Bullet Virginie,Petit-Aubert Gwenaelle,Christin-Maitre Sophie,Fève Bruno,Vatier Camille,Bourcigaux Nathalie,Lautridou Céline,Lahlou Najiba,Bakouboula Prissile,Elie Caroline,Morel Hélène,Treluyer Jean-Marc,Gagnerault Marie-Claude,Maillard Claire,Jones Anna,

Affiliation:

1. INSERM, U1016, Cochin Institute, Paris, France.

2. CNRS, UMR8104, Cochin Institute, Paris, France.

3. Paris Descartes University, Sorbonne Paris Cité, Paris, France.

4. Benaroya Research Institute, Translational Research Program, Seattle, WA 98101, USA.

5. Division of Developmental Immunology, German Cancer Research Center (DKFZ), Heidelberg, Germany.

6. Diabetes Unit, Department of Medicine, Surgery and Neuroscience, University of Siena, and Fondazione Umberto di Mario ONLUS, Toscana Life Sciences, Siena, Italy.

7. CRTD-DFG Research Center for Regenerative Therapies Dresden, Medical Faculty, Technische Universität Dresden, Dresden, Germany.

8. Department of International Health, Immunology and Microbiology, Panum Institute, Copenhagen, Denmark.

9. Division of Infection and Immunity, Cardiff University School of Medicine, Cardiff, UK.

10. Assistance Publique Hôpitaux de Paris, Service de Diabétologie, Cochin Hospital, Paris, France.

11. Centre Hospitalier de Versailles André Mignot, Service de Diabétologie, Le Chesnay, France.

12. Pierre et Marie Curie Paris 6 University, Sorbonne Paris Cité, Département Hospitalo-Universitaire FAST, CR7, Centre d’Immunologie et des Maladies Infectieuses (CIMI-Paris), Paris, France.

13. INSERM, U1135, CIMI-Paris, Paris, France.

14. Barbara Davis Center for Diabetes and Integrated Department of Immunology, University of Colorado Denver Anschutz Medical Campus, Aurora, CO 80045, USA.

15. Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA.

16. Institut für Medizinische Informatik und Biometrie, Medical Faculty, Technische Universität Dresden, Dresden, Germany.

17. Diabetes Research Institute, IRCCS San Raffaele Scientific Institute, Milan, Italy.

18. Assistance Publique Hôpitaux de Paris, Laboratoire d’Immunologie et Histocompatibilité, Hôpital Saint-Louis, Paris, France.

Abstract

Islet-reactive CD8 + T cells are common in the periphery, but home to the pancreas preferentially in the context of type 1 diabetes.

Funder

National Institutes of Health

JDRF

European Research Council

Agence Nationale de la Recherche

Assistance Publique Hôpitaux de Paris

Fondation pour la Recherche Médicale

INSERM-Transfert

Ile de France

Aviesan/Astra Zeneca

Societé Francophone du Diabète

Innovative Medicines Initiative 2 Joint Undertaking

Fondation Bettencourt-Schueller

Publisher

American Association for the Advancement of Science (AAAS)

Subject

General Medicine,Immunology

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