Unresponsiveness to inhaled antigen is governed by conventional dendritic cells and overridden during infection by monocytes

Author:

Bedford James G.1ORCID,Heinlein Melanie23ORCID,Garnham Alexandra L.23ORCID,Nguyen Thi H. O.1ORCID,Loudovaris Tom4ORCID,Ge Chenghao15ORCID,Mannering Stuart I.4ORCID,Elliott Michael67ORCID,Tangye Stuart G.89ORCID,Kedzierska Katherine1ORCID,Gray Daniel H. D.23ORCID,Heath William R.1ORCID,Wakim Linda M.1ORCID

Affiliation:

1. Department of Microbiology and Immunology, University of Melbourne, Peter Doherty Institute for Infection and Immunity, Melbourne, Victoria 3000, Australia.

2. Walter and Eliza Hall Institute of Medical Research, Melbourne, Victoria, Australia.

3. Department of Medical Biology, University of Melbourne, Melbourne, Victoria, Australia.

4. Immunology and Diabetes Unit, St Vincent’s Institute of Medical Research, Fitzroy, Victoria 3065, Australia.

5. School of Medicine, Tsinghua University, Beijing, China.

6. Sydney Medical School, University of Sydney, Sydney, New South Wales 2006, Australia.

7. Chris O’Brien Lifehouse Cancer Centre, Royal Prince Alfred Hospital, Camperdown, New South Wales 2050, Australia.

8. Immunity & Inflammation Theme, Garvan Institute of Medical Research, Darlinghurst, New South Wales 2010, Australia.

9. St Vincent’s Clinical School, University of New South Wales, Sydney, New South Wales 2052, Australia.

Abstract

Immunity to inhaled antigens is governed by inflammatory signals that alter the composition of DC subsets within the NALTs.

Funder

National Health and Medical Research Council of Australia

Publisher

American Association for the Advancement of Science (AAAS)

Subject

General Medicine,Immunology

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