Enhanced IL-36R signaling promotes barrier impairment and inflammation in skin and intestine-Reference-Cited by-同舟云学术

Enhanced IL-36R signaling promotes barrier impairment and inflammation in skin and intestine

Published:2020-12-18 Issue:54 Volume:5 Page:
ISSN:2470-9468
Container-title:Science Immunology
language:en
Short-container-title:Sci. Immunol.

Author:

Hovhannisyan Zaruhi¹^ORCID,Liu Nengyin¹^ORCID,Khalil-Aguero Sara¹,Panea Casandra¹,VanValkenburgh Jeffrey¹,Zhang Ruoyu¹,Lim Wei Keat¹^ORCID,Bai Yu¹,Fury Wen¹^ORCID,Huang Tammy¹,Garnova Elena¹^ORCID,Fairhurst Jeanette¹^ORCID,Kim Jee¹,Aryal Smita¹,Ajithdoss Dharani¹^ORCID,Oyejide Adelekan¹^ORCID,del Pilar Molina-Portela Maria¹^ORCID,E Hock¹^ORCID,Poueymirou William¹^ORCID,Oristian Nicole Stokes¹^ORCID,Brydges Susannah¹^ORCID,Liu Xia¹^ORCID,Olson William¹^ORCID,Yancopoulos George¹,Murphy Andrew J.¹^ORCID,Sleeman Matthew A.¹^ORCID,Haxhinasto Sokol¹^ORCID

Affiliation:

1. Regeneron Pharmaceuticals Inc., Tarrytown, NY 10591, USA.

Abstract

Unrestrained IL-36R signaling in a humanized mouse model causes barrier impairment and increased cutaneous and intestinal inflammation.

Funder

Regeneron Pharmaceuticals

Publisher

American Association for the Advancement of Science (AAAS)

Subject

General Medicine,Immunology

Reference85 articles.

1. IL-1 family nomenclature