Origins and clonal convergence of gastrointestinal IgE + B cells in human peanut allergy

Author:

Hoh Ramona A.1ORCID,Joshi Shilpa A.1ORCID,Lee Ji-Yeun1ORCID,Martin Brock A.1,Varma Sushama1,Kwok Shirley1,Nielsen Sandra C. A.1ORCID,Nejad Parastu1,Haraguchi Emily1,Dixit Priya S.1,Shutthanandan Swetha V.1,Roskin Krishna M.234ORCID,Zhang Wenming5,Tupa Dana5ORCID,Bunning Bryan J.5,Manohar Monali5,Tibshirani Robert67ORCID,Fernandez-Becker Nielsen Q.8,Kambham Neeraja1ORCID,West Robert B.1ORCID,Hamilton Robert G.9,Tsai Mindy15,Galli Stephen J.1510ORCID,Chinthrajah Rebecca S.511,Nadeau Kari C.511ORCID,Boyd Scott D.15ORCID

Affiliation:

1. Department of Pathology, Stanford University School of Medicine, Stanford, CA 94305, USA.

2. Department of Pediatrics, University of Cincinnati, College of Medicine, Cincinnati, OH 45267, USA.

3. Division of Biomedical Informatics, Cincinnati Children’s Hospital Medical Center, Cincinnati, OH 45229, USA.

4. Division of Immunobiology, Cincinnati Children’s Hospital Medical Center, Cincinnati, OH 45229, USA.

5. Sean N. Parker Center for Allergy and Asthma Research, Stanford University School of Medicine, Stanford, CA 94305, USA.

6. Department of Biomedical Data Sciences, Stanford University, Stanford, CA 94305, USA.

7. Department of Statistics, Stanford University, Stanford, CA 94305, USA.

8. Division of Gastroenterology and Hepatology, Department of Medicine, Stanford University School of Medicine, Stanford, CA 94305, USA.

9. Division of Allergy and Clinical Immunology, Department of Medicine, and Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.

10. Department of Microbiology and Immunology, Stanford University School of Medicine, Stanford, CA 94305, USA.

11. Division of Pulmonary, Allergy and Critical Care Medicine and Division of Allergy, Immunology and Rheumatology, Stanford University, Stanford, CA 94305, USA.

Abstract

Peanut-allergic patient GI tissues implicate local IgE class-switching and common IgH genetic rearrangements in pathogenesis.

Funder

National Institutes of Health

National Institute of Allergy and Infectious Diseases

Naddisy Foundation

Sean N. Parker Center for Allergy and Asthma Research at Stanford University

Food Allergy Research and Education Center of Excellence

Myra Reinhard Foundation

End Allergies Together

Li Ka Shing Foundation

Hartman Family Foundation

Crown Family Foundation

Publisher

American Association for the Advancement of Science (AAAS)

Subject

General Medicine,Immunology

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