Comprehensive mapping of immune perturbations associated with severe COVID-19

Author:

Kuri-Cervantes Leticia12ORCID,Pampena Maria Betina12ORCID,Meng Wenzhao3,Rosenfeld Aaron M.3,Ittner Caroline A. G.4,Weisman Ariel R.4ORCID,Agyekum Roseline S.4ORCID,Mathew Divij15ORCID,Baxter Amy E.15ORCID,Vella Laura A.26ORCID,Kuthuru Oliva25ORCID,Apostolidis Sokratis A.257ORCID,Bershaw Luanne25ORCID,Dougherty Jeanette25ORCID,Greenplate Allison R.25ORCID,Pattekar Ajinkya28ORCID,Kim Justin25ORCID,Han Nicholas25ORCID,Gouma Sigrid12ORCID,Weirick Madison E.12ORCID,Arevalo Claudia P.12ORCID,Bolton Marcus J.12ORCID,Goodwin Eileen C.12,Anderson Elizabeth M.12ORCID,Hensley Scott E.12ORCID,Jones Tiffanie K.4ORCID,Mangalmurti Nilam S.24ORCID,Luning Prak Eline T.3ORCID,Wherry E. John259ORCID,Meyer Nuala J.4ORCID,Betts Michael R.12ORCID

Affiliation:

1. Department of Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.

2. Institute for Immunology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.

3. Department of Pathology and Laboratory Medicine, Perelman School of Medicine, Philadelphia, PA 19104, USA.

4. Division of Pulmonary, Allergy and Critical Care, Center for Translational Lung Biology, Lung Biology Institute, Department of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.

5. Department of Systems Pharmacology and Translational Therapeutics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.

6. Division of Infectious Diseases, Department of Pediatrics, Children’s Hospital of Philadelphia, Philadelphia, PA 19104, USA.

7. Division of Rheumatology, Department of Medicine, Hospital of the University of Pennsylvania, Philadelphia, PA 19104, USA.

8. Division of Gastroenterology, Department of Medicine, Hospital of the University of Pennsylvania, Philadelphia, PA 19104, USA.

9. Parker Institute for Cancer Immunotherapy at the University of Pennsylvania, Philadelphia, PA 19104, USA.

Abstract

Profound plasmablast expansion, innate cell modulation, and T cell activation are defining features of severe COVID-19.

Funder

National Institutes of Health

National Institute of Allergy and Infectious Diseases

Publisher

American Association for the Advancement of Science (AAAS)

Subject

General Medicine,Immunology

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