Immune checkpoint blockade sensitivity and progression-free survival associates with baseline CD8 + T cell clone size and cytotoxicity-Reference-Cited by-同舟云学术

Immune checkpoint blockade sensitivity and progression-free survival associates with baseline CD8 + T cell clone size and cytotoxicity

Published:2021-10-29 Issue:64 Volume:6 Page:
ISSN:2470-9468
Container-title:Science Immunology
language:en
Short-container-title:Sci. Immunol.

Author:

Watson Robert A.¹²³^ORCID,Tong Orion¹²^ORCID,Cooper Rosalin¹²^ORCID,Taylor Chelsea A.¹²^ORCID,Sharma Piyush K.¹²^ORCID,de los Aires Alba Verge¹²^ORCID,Mahé Elise A.¹²,Ruffieux Hélène³^ORCID,Nassiri Isar¹²,Middleton Mark R.²⁴^ORCID,Fairfax Benjamin P.¹²⁴

Affiliation:

1. MRC Weatherall Institute of Molecular Medicine, University of Oxford, Headington, Oxford OX3 9DU, UK.

2. Department of Oncology, University of Oxford, Old Road Campus Research Building, Oxford OX3 7DQ, UK.

3. MRC Biostatistics Unit, University of Cambridge, Cambridge Biomedical Campus, Cambridge, CB2 0SR, UK.

4. Oxford Cancer and Haematology Centre, Oxford University Hospitals NHS Foundation Trust, Churchill Hospital, Oxford OX3 7LE, UK.

Abstract

The cytotoxicity and clone size of CD8 + T cell pretreatment are prognostic for immune checkpoint blockade.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

General Medicine,Immunology

Reference51 articles.

1. Immune Checkpoint Blockade in Cancer Therapy

2. Five-Year Survival with Combined Nivolumab and Ipilimumab in Advanced Melanoma

3. Tumor Mutational Burden as an Independent Predictor of Response to Immunotherapy in Diverse Cancers

4. Tumor Mutational Burden and Efficacy of Immune Checkpoint Inhibitors: A Systematic Review and Meta-Analysis

5. Development of tumor mutation burden as an immunotherapy biomarker: utility for the oncology clinic

Cited by 47 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. Lymphocyte T Subsets and Outcome of Immune Checkpoint Inhibitors in Melanoma Patients: An Oncologist’s Perspective on Current Knowledge;International Journal of Molecular Sciences;2024-08-31

2. Bacterial and cancerous cell membrane fused liposome coordinates with PD-L1 inhibitor for cancer immunotherapy;Nano Research;2024-08-03

3. Immune checkpoint therapy responders display early clonal expansion of tumor infiltrating lymphocytes;OncoImmunology;2024-04-26

4. Severe acute myositis and myocarditis on initiation of 6-weekly pembrolizumab post-COVID-19 mRNA vaccination;Journal for ImmunoTherapy of Cancer;2024-04

5. A Responsive DNA Hydrogel Containing Poly‐Aptamers as Dual‐Target Inhibitors for Localized Cancer Immunotherapy;Advanced Functional Materials;2024-03-22