Immune checkpoint blockade sensitivity and progression-free survival associates with baseline CD8 + T cell clone size and cytotoxicity-Reference-Cited by-同舟云学术

Immune checkpoint blockade sensitivity and progression-free survival associates with baseline CD8 + T cell clone size and cytotoxicity

Published:2021-10-29 Issue:64 Volume:6 Page:
ISSN:2470-9468
Container-title:Science Immunology
language:en
Short-container-title:Sci. Immunol.

Author:

Watson Robert A.¹²³^ORCID,Tong Orion¹²^ORCID,Cooper Rosalin¹²^ORCID,Taylor Chelsea A.¹²^ORCID,Sharma Piyush K.¹²^ORCID,de los Aires Alba Verge¹²^ORCID,Mahé Elise A.¹²,Ruffieux Hélène³^ORCID,Nassiri Isar¹²,Middleton Mark R.²⁴^ORCID,Fairfax Benjamin P.¹²⁴

Affiliation:

1. MRC Weatherall Institute of Molecular Medicine, University of Oxford, Headington, Oxford OX3 9DU, UK.

2. Department of Oncology, University of Oxford, Old Road Campus Research Building, Oxford OX3 7DQ, UK.

3. MRC Biostatistics Unit, University of Cambridge, Cambridge Biomedical Campus, Cambridge, CB2 0SR, UK.

4. Oxford Cancer and Haematology Centre, Oxford University Hospitals NHS Foundation Trust, Churchill Hospital, Oxford OX3 7LE, UK.

Abstract

The cytotoxicity and clone size of CD8 + T cell pretreatment are prognostic for immune checkpoint blockade.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

General Medicine,Immunology

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