Human DNA-PK activates a STING-independent DNA sensing pathway-Reference-Cited by-同舟云学术

Human DNA-PK activates a STING-independent DNA sensing pathway

Published:2020-01-03 Issue:43 Volume:5 Page:
ISSN:2470-9468
Container-title:Science Immunology
language:en
Short-container-title:Sci. Immunol.

Author:

Burleigh Katelyn¹^ORCID,Maltbaek Joanna H.¹^ORCID,Cambier Stephanie¹,Green Richard¹,Gale Michael¹²^ORCID,James Richard C.³⁴^ORCID,Stetson Daniel B.¹²^ORCID

Affiliation:

1. Department of Immunology, University of Washington School of Medicine, 750 Republican St., Seattle, WA 98109, USA.

2. Center for Innate Immunity and Immune Disease, University of Washington School of Medicine, 750 Republican St., Seattle, WA 98109, USA.

3. Center for Immunity and Immunotherapies, Seattle Children’s Research Institute, 1900 9th Avenue, Seattle, WA 98101, USA.

4. Department of Pediatrics, University of Washington School of Medicine, 1959 NE Pacific Street, Seattle, WA 98195, USA.

Abstract

Burleigh et al. report a STING-independent DNA sensing pathway in human cells that relies on DNA-PK.

Funder

National Science Foundation

National Institutes of Health

Howard Hughes Medical Institute

Burroughs Wellcome Fund

Publisher

American Association for the Advancement of Science (AAAS)

Subject

General Medicine,Immunology

Reference52 articles.

1. Cytosolic Sensing of Viruses

2. Intracellular Nucleic Acid Detection in Autoimmunity

3. The cGAS–cGAMP–STING pathway connects DNA damage to inflammation, senescence, and cancer

4. Cyclic GMP-AMP Synthase Is a Cytosolic DNA Sensor That Activates the Type I Interferon Pathway

5. Cyclic GMP-AMP Is an Endogenous Second Messenger in Innate Immune Signaling by Cytosolic DNA

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