Gut microbiota–specific IgA + B cells traffic to the CNS in active multiple sclerosis

Author:

Pröbstel Anne-Katrin12ORCID,Zhou Xiaoyuan1ORCID,Baumann Ryan1,Wischnewski Sven3ORCID,Kutza Michael3ORCID,Rojas Olga L.4ORCID,Sellrie Katrin5,Bischof Antje1ORCID,Kim Kicheol1ORCID,Ramesh Akshaya1,Dandekar Ravi1ORCID,Greenfield Ariele L.1ORCID,Schubert Ryan D.1ORCID,Bisanz Jordan E.67ORCID,Vistnes Stephanie8ORCID,Khaleghi Khashayar4,Landefeld James1ORCID,Kirkish Gina1ORCID,Liesche-Starnecker Friederike9,Ramaglia Valeria3ORCID,Singh Sneha1ORCID,Tran Edwina B.1,Barba Patrick1ORCID,Zorn Kelsey1ORCID,Oechtering Johanna2,Forsberg Karin10ORCID,Shiow Lawrence R.811,Henry Roland G.1ORCID,Graves Jennifer1,Cree Bruce A. C.1,Hauser Stephen L.1ORCID,Kuhle Jens2,Gelfand Jeffrey M.1ORCID,Andersen Peter M.10,Schlegel Jürgen9,Turnbaugh Peter J.67ORCID,Seeberger Peter H.5ORCID,Gommerman Jennifer L.4ORCID,Wilson Michael R.1ORCID,Schirmer Lucas312ORCID,Baranzini Sergio E.11314ORCID

Affiliation:

1. Department of Neurology, UCSF Weill Institute for Neurosciences, University of California, San Francisco, San Francisco, CA 94158, USA.

2. Neurologic Clinic and Policlinic and Research Center for Clinical Neuroimmunology and Neuroscience Basel, Departments of Medicine, Biomedicine, and Clinical Research, University Hospital of Basel, University of Basel, 4031 Basel, Switzerland.

3. Department of Neurology and Mannheim Center for Translational Neurosciences, Medical Faculty Mannheim, University of Heidelberg, 68167 Mannheim, Germany.

4. Department of Immunology, University of Toronto, Toronto, ON M5S 18A, Canada.

5. Department of Biomolecular Systems, Max Planck Institute of Colloids and Interfaces, 14776 Potsdam, Germany.

6. Department of Microbiology and Immunology, University of California, San Francisco, San Francisco, CA 94143, USA.

7. Chan Zuckerberg Biohub, San Francisco, CA 94158, USA.

8. Eli and Edythe Broad Center for Stem Cell Research and Regeneration Medicine, University of California, San Francisco, San Francisco, CA 94143, USA.

9. Department of Neuropathology, School of Medicine, Institute of Pathology, Technical University Munich, 81675 Munich, Germany.

10. Department of Clinical Science, Neurosciences, Umeå University, 90185 Umeå, Sweden.

11. Department of Pediatrics, University of California, San Francisco, San Francisco, CA 94158, USA.

12. Interdisciplinary Center for Neurosciences, University of Heidelberg, 69117 Heidelberg, Germany.

13. Institute for Human Genetics, University of California, San Francisco, San Francisco, CA 94143, USA.

14. Graduate Program in Bioinformatics, University of California, San Francisco, San Francisco, CA 94158, USA.

Abstract

IgA + cells act as a systemic mediator between the gut and the central nervous system during active multiple sclerosis.

Funder

National Multiple Sclerosis Society

Swiss National Science Foundation

Valhalla Charitable Foundation

Publisher

American Association for the Advancement of Science (AAAS)

Subject

General Medicine,Immunology

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