Gut microbiota–specific IgA + B cells traffic to the CNS in active multiple sclerosis

Author:

Pröbstel Anne-Katrin12ORCID,Zhou Xiaoyuan1ORCID,Baumann Ryan1,Wischnewski Sven3ORCID,Kutza Michael3ORCID,Rojas Olga L.4ORCID,Sellrie Katrin5,Bischof Antje1ORCID,Kim Kicheol1ORCID,Ramesh Akshaya1,Dandekar Ravi1ORCID,Greenfield Ariele L.1ORCID,Schubert Ryan D.1ORCID,Bisanz Jordan E.67ORCID,Vistnes Stephanie8ORCID,Khaleghi Khashayar4,Landefeld James1ORCID,Kirkish Gina1ORCID,Liesche-Starnecker Friederike9,Ramaglia Valeria3ORCID,Singh Sneha1ORCID,Tran Edwina B.1,Barba Patrick1ORCID,Zorn Kelsey1ORCID,Oechtering Johanna2,Forsberg Karin10ORCID,Shiow Lawrence R.811,Henry Roland G.1ORCID,Graves Jennifer1,Cree Bruce A. C.1,Hauser Stephen L.1ORCID,Kuhle Jens2,Gelfand Jeffrey M.1ORCID,Andersen Peter M.10,Schlegel Jürgen9,Turnbaugh Peter J.67ORCID,Seeberger Peter H.5ORCID,Gommerman Jennifer L.4ORCID,Wilson Michael R.1ORCID,Schirmer Lucas312ORCID,Baranzini Sergio E.11314ORCID

Affiliation:

1. Department of Neurology, UCSF Weill Institute for Neurosciences, University of California, San Francisco, San Francisco, CA 94158, USA.

2. Neurologic Clinic and Policlinic and Research Center for Clinical Neuroimmunology and Neuroscience Basel, Departments of Medicine, Biomedicine, and Clinical Research, University Hospital of Basel, University of Basel, 4031 Basel, Switzerland.

3. Department of Neurology and Mannheim Center for Translational Neurosciences, Medical Faculty Mannheim, University of Heidelberg, 68167 Mannheim, Germany.

4. Department of Immunology, University of Toronto, Toronto, ON M5S 18A, Canada.

5. Department of Biomolecular Systems, Max Planck Institute of Colloids and Interfaces, 14776 Potsdam, Germany.

6. Department of Microbiology and Immunology, University of California, San Francisco, San Francisco, CA 94143, USA.

7. Chan Zuckerberg Biohub, San Francisco, CA 94158, USA.

8. Eli and Edythe Broad Center for Stem Cell Research and Regeneration Medicine, University of California, San Francisco, San Francisco, CA 94143, USA.

9. Department of Neuropathology, School of Medicine, Institute of Pathology, Technical University Munich, 81675 Munich, Germany.

10. Department of Clinical Science, Neurosciences, Umeå University, 90185 Umeå, Sweden.

11. Department of Pediatrics, University of California, San Francisco, San Francisco, CA 94158, USA.

12. Interdisciplinary Center for Neurosciences, University of Heidelberg, 69117 Heidelberg, Germany.

13. Institute for Human Genetics, University of California, San Francisco, San Francisco, CA 94143, USA.

14. Graduate Program in Bioinformatics, University of California, San Francisco, San Francisco, CA 94158, USA.

Abstract

IgA + cells act as a systemic mediator between the gut and the central nervous system during active multiple sclerosis.

Funder

National Multiple Sclerosis Society

Swiss National Science Foundation

Valhalla Charitable Foundation

Publisher

American Association for the Advancement of Science (AAAS)

Subject

General Medicine,Immunology

同舟云学术

1.学者识别学者识别

2.学术分析学术分析

3.人才评估人才评估

"同舟云学术"是以全球学者为主线,采集、加工和组织学术论文而形成的新型学术文献查询和分析系统,可以对全球学者进行文献检索和人才价值评估。用户可以通过关注某些学科领域的顶尖人物而持续追踪该领域的学科进展和研究前沿。经过近期的数据扩容,当前同舟云学术共收录了国内外主流学术期刊6万余种,收集的期刊论文及会议论文总量共计约1.5亿篇,并以每天添加12000余篇中外论文的速度递增。我们也可以为用户提供个性化、定制化的学者数据。欢迎来电咨询!咨询电话:010-8811{复制后删除}0370

www.globalauthorid.com

TOP

Copyright © 2019-2024 北京同舟云网络信息技术有限公司
京公网安备11010802033243号  京ICP备18003416号-3