Evading the Toll booth: How “silent” flagellins may bind yet fail to activate TLR5-Reference-Cited by-同舟云学术

Evading the Toll booth: How “silent” flagellins may bind yet fail to activate TLR5

Published:2023-01-13 Issue:79 Volume:8 Page:
ISSN:2470-9468
Container-title:Science Immunology
language:en
Short-container-title:Sci. Immunol.

Author:

Baer Hannah M.¹²^ORCID,Sandilya Shruti¹,Steiner Theodore S.¹

Affiliation:

1. BC Children’s Hospital Research Institute, Vancouver, BC, Canada.

2. Institute of Infection, Inflammation & Immunity, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow, UK.

Abstract

The nature of flagellin–Toll-like receptor 5 (TLR5) interactions, depending on binding to and activation of TLR5, may hold a key to the distinct differences in gut microbiome and intestinal immune function in different populations around the world (see related Research Article by Clasen et al .).

Publisher

American Association for the Advancement of Science (AAAS)

Subject

General Medicine,Immunology

Link

https://www.science.org/doi/pdf/10.1126/sciimmunol.adf0244

Reference10 articles.

1. Toll-like receptor 5 recognizes a conserved site on flagellin required for protofilament formation and bacterial motility

2. S. J. Clasen M. E. W. Bell D.-H. Lee Z. M. Henseler A. Borbón J. de la Cuesta-Zuluaga K. Parys J. Zou N. D. Youngblut A. T. Gewirtz Y. Belkhadir R. E. Ley Silent recognition of flagellins from human gut commensal bacteria by Toll-like receptor 5. bioRxiv 2022.04.12.488020 (2022).

3. Bacterial flagellin is a dominant antigen in Crohn disease

4. Dominant-negative TLR5 polymorphism reduces adaptive immune response to flagellin and negatively associates with Crohn's disease

5. Evasion of Toll-like receptor 5 by flagellated bacteria

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