Human airway mast cells proliferate and acquire distinct inflammation-driven phenotypes during type 2 inflammation

Author:

Dwyer Daniel F.12ORCID,Ordovas-Montanes Jose3456ORCID,Allon Samuel J.578ORCID,Buchheit Kathleen M.12,Vukovic Marko578,Derakhshan Tahereh12ORCID,Feng Chunli12ORCID,Lai Juying12,Hughes Travis K.578,Nyquist Sarah K.5789,Giannetti Matthew P.12ORCID,Berger Bonnie10ORCID,Bhattacharyya Neil211ORCID,Roditi Rachel E.211ORCID,Katz Howard R.12,Nawijn Martijn C.1213ORCID,Berg Marijn1213,van den Berge Maarten1214,Laidlaw Tanya M.12ORCID,Shalek Alex K.578ORCID,Barrett Nora A.124ORCID,Boyce Joshua A.124ORCID

Affiliation:

1. Jeff and Penny Vinik Immunology Center, Division of Allergy and Clinical Immunology, Brigham and Women’s Hospital, Boston, MA, USA.

2. Department of Medicine, Harvard Medical School, Boston, MA, USA.

3. Division of Gastroenterology, Boston Children’s Hospital, Boston, MA, USA.

4. Program in Immunology, Harvard Medical School, Boston, MA, USA.

5. Broad Institute of MIT and Harvard, Cambridge, MA, USA.

6. Harvard Stem Cell Institute, Cambridge, MA, USA.

7. Institute for Medical Engineering and Science (IMES), Department of Chemistry, and Koch Institute for Integrative Cancer Research, MIT, Cambridge, MA, USA.

8. Ragon Institute of MGH, MIT and Harvard, Cambridge, MA, USA.

9. Program in Computational and Systems Biology, MIT, Cambridge, MA, USA.

10. Computer Science and Artificial Intelligence Lab and Department of Mathematics, MIT, Cambridge, MA, USA.

11. Department of Surgery, Brigham and Women’s Hospital, Boston, MA, USA.

12. Groningen Research Institute for Asthma and COPD, University Medical Center Groningen, University of Groningen, Groningen, Netherlands.

13. Department of Pathology and Medical Biology, Laboratory of Experimental Immunology and Respiratory Research (EXPIRE), University Medical Center Groningen, University of Groningen, Groningen, Netherlands.

14. Department of Pulmonary Diseases, University Medical Center Groningen, University of Groningen, Groningen, Netherlands.

Abstract

Mast cells in type 2 airway inflammation exhibit heterogeneous inflammation-associated phenotypes and proliferate in situ.

Funder

National Institutes of Health

Bill and Melinda Gates Foundation

Alfred P. Sloan Foundation

National Institute of Allergy and Infectious Diseases

Damon Runyon Cancer Research Foundation

Searle Scholars Program

Beckman Young Investigator Program

Pew-Stewart Scholars Program for Cancer Research

Steven and Judy Kaye Young Innovators Award

European Commission Directorate-General for Research and Innovation

Food Allergy Science Initiative

AGA Research Foundation’s AGA-Takeda Pharmaceuticals Research Scholar Award in IBD

Richard and Susan Smith Family Foundation

New York Stem Cell Foundation

Publisher

American Association for the Advancement of Science (AAAS)

Subject

General Medicine,Immunology

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