Inhibitory killer cell immunoglobulin-like receptors strengthen CD8 + T cell–mediated control of HIV-1, HCV, and HTLV-1

Author:

Boelen Lies1ORCID,Debebe Bisrat1ORCID,Silveira Marcos12,Salam Arafa3,Makinde Julia4ORCID,Roberts Chrissy h.5ORCID,Wang Eddie C. Y.6ORCID,Frater John78ORCID,Gilmour Jill4,Twigger Katie1,Ladell Kristin6ORCID,Miners Kelly L.6,Jayaraman Jyothi9,Traherne James A.9ORCID,Price David A.6ORCID,Qi Ying10,Martin Maureen P.10ORCID,Macallan Derek C.3ORCID,Thio Chloe L.11ORCID,Astemborski Jacquie11,Kirk Gregory11ORCID,Donfield Sharyne M.12,Buchbinder Susan13,Khakoo Salim I.14ORCID,Goedert James J.15ORCID,Trowsdale John9,Carrington Mary1016ORCID,Kollnberger Simon6ORCID,Asquith Becca1ORCID,

Affiliation:

1. Department of Medicine, Imperial College London, London, UK.

2. Faculty of Engineering, São Paulo State University—UNESP, São Paulo, Brazil.

3. Institute for Infection and Immunity, St. George’s, University of London, London, UK.

4. International AIDS Vaccine Initiative Human Immunology Laboratory, London, UK.

5. Clinical Research Department, London School of Hygiene and Tropical Medicine, London, UK.

6. Division of Infection and Immunity, Cardiff University School of Medicine, Cardiff, UK.

7. Nuffield Department of Medicine, University of Oxford, Oxford, UK.

8. Oxford NIHR Biomedical Research Centre, Oxford, UK.

9. Immunology Division, Department of Pathology, University of Cambridge, Cambridge, UK.

10. Cancer and Inflammation Program, Leidos Biomedical Research Inc., Frederick National Laboratory for Cancer Research, Frederick, MD, USA.

11. Johns Hopkins University, Baltimore, MD, USA.

12. Rho, Chapel Hill, NC, USA.

13. San Francisco Department of Public Health, San Francisco, CA, USA.

14. Faculty of Medicine, University of Southampton, Southampton, UK.

15. Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD, USA.

16. Ragon Institute of MGH, MIT and Harvard, Boston, MA, USA.

Abstract

Inhibitory killer cell immunoglobulin-like receptors (iKIRs) help maintain CD8 + T cell responses to human chronic viral infections.

Funder

National Institutes of Health

National Institute on Drug Abuse

National Institute of Child Health and Human Development

H2020 European Research Council

Wellcome Trust

Medical Research Council

Frederick National Laboratory for Cancer Research

United States Agency for International Development

Cambridge Biomedical Research Centre

European Union FP7

Bloodwise

Intramural Research Program of the NIH, Frederick National Laboratory, Center for Cancer Research

Brazilian National Council for Scientific Development

WT Institutional Strategic Support Fund

Publisher

American Association for the Advancement of Science (AAAS)

Subject

General Medicine,Immunology

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