Early-life programming of mesenteric lymph node stromal cell identity by the lymphotoxin pathway regulates adult mucosal immunity-Reference-Cited by-同舟云学术

Early-life programming of mesenteric lymph node stromal cell identity by the lymphotoxin pathway regulates adult mucosal immunity

Published:2019-12-06 Issue:42 Volume:4 Page:
ISSN:2470-9468
Container-title:Science Immunology
language:en
Short-container-title:Sci. Immunol.

Author:

Li Conglei¹^ORCID,Lam Evelyn¹,Perez-Shibayama Christian²,Ward Lesley A.¹,Zhang Jianbo³^ORCID,Lee Dennis¹^ORCID,Nguyen Albert¹^ORCID,Ahmed Musaddeque⁴^ORCID,Brownlie Emma⁵,Korneev Kirill V.⁶^ORCID,Rojas Olga¹^ORCID,Sun Tian¹^ORCID,Navarre William⁵^ORCID,He Housheng Hansen⁴^ORCID,Liao Shan³^ORCID,Martin Alberto¹^ORCID,Ludewig Burkhard²^ORCID,Gommerman Jennifer L.¹^ORCID

Affiliation:

1. Department of Immunology, University of Toronto, Toronto, Ontario, Canada.

2. Institute of Immunobiology, Kantonsspital St. Gallen, St. Gallen, Switzerland.

3. Department of Microbiology, Immunology and Infectious Diseases, Snyder Institute for Chronic Diseases, Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada.

4. Department of Medical Biophysics, University of Toronto, Princess Margaret Hospital, Toronto, Ontario, Canada.

5. Department of Molecular Genetics, University of Toronto, Toronto, Ontario, Canada.

6. Engelhardt Institute of Molecular Biology, Russian Academy of Sciences and Department of Immunology, Biological Faculty, Lomonosov Moscow State University, Moscow, Russia.

Abstract

Early-life LTβR signaling programs the mesenteric lymph node stromal cell environment, optimizing gut IgA responses in the adult mouse.

Funder

Princess Margaret Cancer Foundation

Foundation grant from the Canadian Institutes of Health Research

Project grant from the Canadian Institutes of Health Research

Canadian Institutes of Health Research Postdoctoral Fellowship

Publisher

American Association for the Advancement of Science (AAAS)

Subject

General Medicine,Immunology

Reference91 articles.