Human IFN-γ immunity to mycobacteria is governed by both IL-12 and IL-23

Author:

Martínez-Barricarte Rubén1,Markle Janet G.1ORCID,Ma Cindy S.2ORCID,Deenick Elissa K.2ORCID,Ramírez-Alejo Noé1ORCID,Mele Federico3ORCID,Latorre Daniela3,Mahdaviani Seyed Alireza4ORCID,Aytekin Caner5ORCID,Mansouri Davood4,Bryant Vanessa L.678ORCID,Jabot-Hanin Fabienne9ORCID,Deswarte Caroline910,Nieto-Patlán Alejandro9ORCID,Surace Laura11ORCID,Kerner Gaspard910ORCID,Itan Yuval112,Jovic Sandra3ORCID,Avery Danielle T.2,Wong Natalie2,Rao Geetha2,Patin Etienne131415ORCID,Okada Satoshi16ORCID,Bigio Benedetta1,Boisson Bertrand1910ORCID,Rapaport Franck1ORCID,Seeleuthner Yoann910,Schmidt Monika17,Ikinciogullari Aydan18,Dogu Figen18,Tanir Gonul19,Tabarsi Payam4,Bloursaz Mohammed Reza4,Joseph Julia K.1,Heer Avneet1,Kong Xiao-Fei1ORCID,Migaud Mélanie910ORCID,Lazarov Tomi20ORCID,Geissmann Frédéric202122ORCID,Fleckenstein Bernhard17,Arlehamn Cecilia Lindestam23ORCID,Sette Alessandro2324ORCID,Puel Anne1910ORCID,Emile Jean-François25ORCID,van de Vosse Esther26ORCID,Quintana-Murci Lluis131415ORCID,Di Santo James P.11ORCID,Abel Laurent1910ORCID,Boisson-Dupuis Stéphanie1910ORCID,Bustamante Jacinta191027,Tangye Stuart G.2ORCID,Sallusto Federica328ORCID,Casanova Jean-Laurent19102930ORCID

Affiliation:

1. St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, Rockefeller University, New York, NY, USA.

2. Immunology Division, Garvan Institute of Medical Research and St Vincent’s Clinical School, Faculty of Medicine, University of NSW, Sydney, New South Wales, Australia.

3. Center of Medical Immunology, Institute for Research in Biomedicine, Faculty of Biomedical Sciences, University of italian Switzerland (USI), Bellinzona, Switzerland.

4. Pediatric Respiratory Diseases Research Center, National Research Institute of Tuberculosis and Lung Diseases (NRITLD), Shahid Beheshti University of Medical Sciences, Tehran, Iran.

5. Department of Pediatric Immunology, Dr. Sami Ulus Maternity and Children's Health and Diseases Training and Research Hospital, Ankara, Turkey.

6. Immunology Division, Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria, Australia.

7. Department of Medical Biology, University of Melbourne, Parkville, Victoria, Australia.

8. Department of Clinical Immunology and Allergy, Royal Melbourne Hospital, Parkville, Victoria, Australia.

9. Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163, Necker Hospital for Sick Children, Paris, France.

10. Paris Descartes University, Imagine Institute, Paris, France.

11. Innate Immunity Unit, Pasteur Institute, INSERM U1223, Paris, France.

12. Charles Bronfman Institute for Personalized Medicine, and the Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, USA.

13. Human Evolutionary Genetics Unit, Department of Genomes and Genetics, Pasteur Institute, Paris, France.

14. Centre National de la Recherche Scientifique, UMR 2000, Paris, France.

15. Center of Bioinformatics, Biostatistics and Integrative Biology, Pasteur Institute, Paris, France.

16. Department of Pediatrics, Hiroshima University Graduate School of Biomedical & Health Sciences, Hiroshima, Japan.

17. Institute for Clinical and Molecular Virology, University Erlangen-Nuremberg,Erlangen, Germany.

18. Department of Pediatric Immunology and Allergy, Ankara University School of Medicine, Ankara, Turkey.

19. Department of Pediatric Infectious Diseases, Dr. Sami Ulus Maternity and Children's Health and Diseases Training and Research Hospital, Ankara, Turkey.

20. Immunology Program, Memorial Sloan Kettering Cancer Center, New York, NY, USA.

21. Weill Cornell Graduate School of Medical Sciences, New York, NY, USA.

22. Centre for Molecular and Cellular Biology of Inflammation, King’s College London, London, UK.

23. Department of Vaccine Discovery, La Jolla Institute for Allergy and Immunology, La Jolla, CA, USA.

24. Department of Medicine, University of California San Diego, La Jolla, CA, USA.

25. EA4340 and Pathology Department, Ambroise Paré Hospital AP-HP, Versailles Saint-Quentin-en-Yvelines University, Paris-Saclay University, Boulogne, France.

26. Department of Infectious Diseases, Leiden University Medical Center, Leiden, Netherlands.

27. Study Center of Immunodeficiencies, Necker Hospital for Sick Children, AP-HP, Paris, France.

28. Institute of Microbiology, ETH Zurich, Switzerland.

29. Howard Hughes Medical Institute, New York, NY, USA.

30. Pediatric Hematology-Immunology Unit, Necker Hospital for Sick Children AP-HP, Paris, France.

Abstract

Human IFN-γ–dependent immunity to mycobacteria is less compromised in IL-12Rβ2 or IL-23R deficiency than IL-12Rβ1 deficiency.

Funder

National Institutes of Health

National Institute of Allergy and Infectious Diseases

National Center for Research Resources

European Research Council

French National Research Agency

NSW Ministry of Health

Swiss National Science Foundation

National Health and Medical Research Council

Japanese Society for the Promotion of Science

Integrative Biology of Emerging Infectious Diseases Laboratory of Excellence

SRC fondation

NIH Translational Science Award

National Council of Science and Technology of Mexico

Publisher

American Association for the Advancement of Science (AAAS)

Subject

General Medicine,Immunology

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