In vivo genome-wide CRISPR screens identify SOCS1 as intrinsic checkpoint of CD4 + T H 1 cell response-Reference-Cited by-同舟云学术

In vivo genome-wide CRISPR screens identify SOCS1 as intrinsic checkpoint of CD4 + T H 1 cell response

Published:2021-12-24 Issue:66 Volume:6 Page:
ISSN:2470-9468
Container-title:Science Immunology
language:en
Short-container-title:Sci. Immunol.

Author:

Sutra Del Galy Aurélien¹^ORCID,Menegatti Silvia²^ORCID,Fuentealba Jaime²,Lucibello Francesca²,Perrin Laetitia²,Helft Julie²^ORCID,Darbois Aurélie²,Saitakis Michael²^ORCID,Tosello Jimena²^ORCID,Rookhuizen Derek²,Deloger Marc³^ORCID,Gestraud Pierre⁴^ORCID,Socié Gérard¹^ORCID,Amigorena Sebastian²^ORCID,Lantz Olivier²⁵⁶^ORCID,Menger Laurie²^ORCID

Affiliation:

1. AP-HP Hospital Saint Louis, Hematology/Transplantation, Paris 75010, France.

2. INSERM U932, PSL University, Institut Curie, Paris 75005, France.

3. INSERM US23, CNRS UMS 3655, Gustave Roussy Cancer Campus, 94800 Villejuif, France.

4. Bioinformatics and Computational Systems Biology of Cancer, PSL Research University, MINES ParisTech, INSERM U900, Paris 75005, France.

5. Laboratoire d’immunologie clinique, Institut Curie, Paris 75005, France.

6. Centre d’investigation Clinique en Biothérapie Gustave-Roussy Institut Curie (CIC-BT1428), Institut Curie, Paris 75005, France.

Abstract

Inactivation of SOCS1 optimizes adoptive T cell therapy including human CAR-T cell composition and efficacy.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

General Medicine,Immunology

Reference82 articles.

1. The Principles of Engineering Immune Cells to Treat Cancer

2. Eradication of systemic B-cell tumors by genetically targeted human T lymphocytes co-stimulated by CD80 and interleukin-15

3. Regional delivery of mesothelin-targeted CAR T cell therapy generates potent and long-lasting CD4-dependent tumor immunity

4. T-Cell Receptor Gene Therapy: Critical Parameters for Clinical Success

5. CAR therapy: the CD19 paradigm

Cited by 40 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. Unveiling the pathological functions of SOCS in colorectal cancer: Current concepts and future perspectives;Pathology - Research and Practice;2024-10

2. KLF4‐induced upregulation of SOCS1 ameliorates myocardial ischemia/reperfusion injury by attenuating AC16 cardiomyocyte damage and enhancing M2 macrophage polarization;Journal of Biochemical and Molecular Toxicology;2024-08-26

3. SOCS1 is a critical checkpoint in immune homeostasis, inflammation and tumor immunity;Frontiers in Immunology;2024-06-14

4. The Interplay Between Helicobacter pylori and Suppressors of Cytokine Signaling (SOCS) Molecules in the Development of Gastric Cancer and Induction of Immune Response;Helicobacter;2024-05

5. CRISPR–Cas9 applications in T cells and adoptive T cell therapies;Cellular & Molecular Biology Letters;2024-04-12