A fetal wave of human type 3 effector γδ cells with restricted TCR diversity persists into adulthood-Reference-Cited by-同舟云学术

A fetal wave of human type 3 effector γδ cells with restricted TCR diversity persists into adulthood

Published:2021-04-02 Issue:58 Volume:6 Page:
ISSN:2470-9468
Container-title:Science Immunology
language:en
Short-container-title:Sci. Immunol.

Author:

Tan Likai¹²^ORCID,Fichtner Alina Suzann¹^ORCID,Bruni Elena¹^ORCID,Odak Ivan¹^ORCID,Sandrock Inga¹,Bubke Anja¹,Borchers Alina³,Schultze-Florey Christian¹⁴^ORCID,Koenecke Christian¹⁴^ORCID,Förster Reinhold¹⁵,Jarek Michael⁶^ORCID,von Kaisenberg Constantin⁷,Schulz Ansgar⁸^ORCID,Chu Xiaojing⁹¹⁰^ORCID,Zhang Bowen¹⁰^ORCID,Li Yang⁵¹⁰,Panzer Ulf³,Krebs Christian F.³^ORCID,Ravens Sarina¹⁵^ORCID,Prinz Immo¹²⁵^ORCID

Affiliation:

1. Institute of Immunology, Hannover Medical School (MHH), Hannover, Germany.

2. Institute of Systems Immunology, Hamburg Center for Translational Immunology (HCTI), University Medical Center Hamburg-Eppendorf, Hamburg, Germany.

3. Translational Immunology, III. Department of Medicine, Hamburg Center for Translational Immunology (HCTI), University Medical Center Hamburg-Eppendorf, Hamburg, Germany.

4. Department of Hematology, Hemostasis, Oncology, and Stem Cell Transplantation, Hannover Medical School, Hannover, Germany.

5. Cluster of Excellence RESIST (EXC 2155), Hannover Medical School, Hannover, Germany.

6. Genome Analytics, Helmholtz Centre for Infection Research, Braunschweig, Germany.

7. Department of Obstetrics, Gynecology, and Reproductive Medicine, Hannover Medical School, Hannover, Germany.

8. Department of Pediatrics, University Medical Center Ulm, Ulm, Germany.

9. Department of Genetics, University of Groningen, University Medical Center Groningen, Groningen, Netherlands.

10. Department of Computational Biology for Individualised Medicine TWINCORE, Helmholtz Centre for Infection Research and Hannover Medical School, Hannover, Germany.

Abstract

Innate-like human type 3 effector γδ T cells with canonical Vγ9Vδ2 + TCR develop in the earliest fetal thymus and persist into adulthood.

Funder

ASCRS Research Foundation

Deutsche Forschungsgemeinschaft

Publisher

American Association for the Advancement of Science (AAAS)

Subject

General Medicine,Immunology

Reference77 articles.

1. Translating gammadelta (γδ) T cells and their receptors into cancer cell therapies

2. Six-of-the-best: unique contributions of γδ T cells to immunology