3M-052, a synthetic TLR-7/8 agonist, induces durable HIV-1 envelope–specific plasma cells and humoral immunity in nonhuman primates

Author:

Kasturi Sudhir Pai1ORCID,Rasheed Mohammed Ata Ur12ORCID,Havenar-Daughton Colin3ORCID,Pham Mathew1ORCID,Legere Traci1ORCID,Sher Zarpheen Jinnah1,Kovalenkov Yevgeny1ORCID,Gumber Sanjeev1ORCID,Huang Jessica Y.1ORCID,Gottardo Raphael4ORCID,Fulp William4,Sato Alicia4ORCID,Sawant Sheetal56ORCID,Stanfield-Oakley Sherry5ORCID,Yates Nicole56ORCID,LaBranche Celia5ORCID,Alam S. Munir5ORCID,Tomaras Georgia56,Ferrari Guido56,Montefiori David5ORCID,Wrammert Jens1ORCID,Villinger Francois17ORCID,Tomai Mark8ORCID,Vasilakos John8,Fox Christopher B.910ORCID,Reed Steven G.911,Haynes Barton F.5,Crotty Shane312ORCID,Ahmed Rafi12ORCID,Pulendran Bali113ORCID

Affiliation:

1. Emory Vaccine Center and Yerkes National Primate Research Center, Emory University, 954, Gatewood Road, Atlanta, GA, USA.

2. Division of Microbiology and Immunology and Rollins Research Center, Emory University, 1510 Clifton Road, Atlanta, GA, USA.

3. Division of Vaccine Discovery, La Jolla Institute of Immunology, La Jolla, CA, USA.

4. Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Research Center, Seattle, WA, USA.

5. Duke Human Vaccine Institute and Department of Surgery, Duke University Medical Center Durham, NC, USA.

6. Department of Molecular Genetics and Microbiology and Department of Immunology, Duke University, NC, USA.

7. New Iberia Research Center, University of Louisiana Lafayette, New Iberia, LA, USA.

8. 3M Drug Delivery Systems, St. Paul, MN, USA.

9. Infectious Disease Research Institute, Seattle, WA, USA.

10. Department of Global Health, University of Washington, Seattle, WA, USA.

11. HDT Bio, Seattle, WA, USA.

12. Division of Infectious Diseases and Global Public Health, Department of Medicine, University of California, San Diego (UCSD), La Jolla, CA, USA.

13. Departments of Pathology and Microbiology & Immunology, Institute for Immunity, Transplantation and Infection, Stanford University, Stanford, CA, USA.

Abstract

Our study describes robust and durable induction of HIV-1–specific antibody as well as germinal center and plasma cellular responses in rhesus macaques.

Funder

Bill and Melinda Gates Foundation

Publisher

American Association for the Advancement of Science (AAAS)

Subject

General Medicine,Immunology

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