Cytomegaloviral determinants of CD8 + T cell programming and RhCMV/SIV vaccine efficacy

Author:

Malouli Daniel1ORCID,Hansen Scott G.1ORCID,Hancock Meaghan H.1ORCID,Hughes Colette M.1,Ford Julia C.1ORCID,Gilbride Roxanne M.1,Ventura Abigail B.1ORCID,Morrow David1ORCID,Randall Kurt T.1,Taher Husam1,Uebelhoer Luke S.1,McArdle Matthew R.1,Papen Courtney R.1,Espinosa Trethewy Renee1,Oswald Kelli2,Shoemaker Rebecca2,Berkemeier Brian2ORCID,Bosche William J.2ORCID,Hull Michael2,Greene Justin M.1ORCID,Axthelm Michael K.1ORCID,Shao Jason3ORCID,Edlefsen Paul T.3ORCID,Grey Finn4ORCID,Nelson Jay A.1,Lifson Jeffrey D.2ORCID,Streblow Daniel1,Sacha Jonah B.1,Früh Klaus1ORCID,Picker Louis J.1ORCID

Affiliation:

1. Vaccine and Gene Therapy Institute and Oregon National Primate Research Center, Oregon Health and Science University, Beaverton, OR 97006, USA.

2. AIDS and Cancer Virus Program, Frederick National Laboratory for Cancer Research, Leidos Biomedical Research Inc., Frederick, MD 21702, USA.

3. Population Sciences and Computational Biology Programs, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA.

4. Division of Infection and Immunity, Roslin Institute, University of Edinburgh, Edinburgh, UK.

Abstract

Eight RhCMV gene products control induction of unconventionally restricted CD8 + T cells and RhCMV/SIV vaccine efficacy.

Funder

National Institutes of Health

NIH Office of the Director

National Cancer Institute

National Institute of Allergy and Infectious Diseases

Publisher

American Association for the Advancement of Science (AAAS)

Subject

General Medicine,Immunology

Reference39 articles.

1. M. A. Jarvis S. G. Hansen J. A. Nelson L. J. Picker K. Früh in Cytomegaloviruses: From Molecular Pathogenesis to Intervention M. J. Reddehase Ed. (Caister Academic Press 2013) vol. 2 chap. 21.

2. Molecular characterization of HCMV-specific immune responses: Parallels between CD8+T cells, CD4+T cells, and NK cells

3. T cell responses to cytomegalovirus

4. Hidden Memories: Frontline Memory T Cells and Early Pathogen Interception

5. New Paradigms for HIV/AIDS Vaccine Development

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