MR1 displays the microbial metabolome driving selective MR1-restricted T cell receptor usage

Author:

Harriff Melanie J.12ORCID,McMurtrey Curtis3,Froyd Cara A.4ORCID,Jin Haihong5ORCID,Cansler Meghan6,Null Megan6,Worley Aneta1,Meermeier Erin W.2ORCID,Swarbrick Gwendolyn6,Nilsen Aaron157ORCID,Lewinsohn Deborah A.6ORCID,Hildebrand William3,Adams Erin J.4,Lewinsohn David M.12ORCID

Affiliation:

1. VA Portland Health Care System, Research and Development, 3710 Southwest U.S. Veterans Hospital Road, Portland, OR 97239, USA.

2. Department of Pulmonary and Critical Care Medicine, Oregon Health & Science University, 3181 Southwest Sam Jackson Park Road, Portland, OR 97239, USA.

3. Department of Microbiology and Immunology, University of Oklahoma Health Sciences Center, Oklahoma City, OK 73104, USA.

4. Department of Biochemistry and Molecular Biology, University of Chicago, Chicago, IL 60637, USA.

5. Oregon Health & Science University Medicinal Chemistry Core, Portland, OR 97239, USA.

6. Department of Pediatrics, Oregon Health & Science University, Portland, OR 97239, USA.

7. Department of Molecular Microbiology and Immunology, Oregon Health & Science University, Portland, OR 97239, USA.

Abstract

A diverse array of microbial metabolites binds to MR1 and selectively activates MR1-restricted T cells.

Funder

Bill and Melinda Gates Foundation

Publisher

American Association for the Advancement of Science (AAAS)

Subject

General Medicine,Immunology

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