Salivary gland macrophages and tissue-resident CD8 + T cells cooperate for homeostatic organ surveillance

Author:

Stolp Bettina12ORCID,Thelen Flavian1ORCID,Ficht Xenia1ORCID,Altenburger Lukas M.3ORCID,Ruef Nora3ORCID,Inavalli V. V. G. Krishna45ORCID,Germann Philipp67ORCID,Page Nicolas8,Moalli Federica9,Raimondi Andrea9ORCID,Keyser Kirsten A.10,Seyed Jafari S. Morteza11ORCID,Barone Francesca12,Dettmer Matthias S.13ORCID,Merkler Doron8ORCID,Iannacone Matteo9ORCID,Sharpe James6714,Schlapbach Christoph11ORCID,Fackler Oliver T.2,Nägerl U. Valentin45ORCID,Stein Jens V.3ORCID

Affiliation:

1. Theodor Kocher Institute, University of Bern, 3012 Bern, Switzerland.

2. Department for Infectious Diseases, Integrative Virology, Center for Integrative Infectious Disease Research, University Hospital Heidelberg, Im Neuenheimer Feld 344, 69120 Heidelberg, Germany.

3. Department of Oncology, Microbiology and Immunology, University of Fribourg, 1700 Fribourg, Switzerland.

4. University of Bordeaux, 33700 Bordeaux, France.

5. Interdisciplinary Institute for Neuroscience, CNRS UMR 5297, 33077 Bordeaux, France.

6. EMBL Barcelona, Dr. Aiguader 88, 08003 Barcelona, Spain.

7. Universitat Pompeu Fabra (UPF), 08002 Barcelona, Spain.

8. Department of Pathology and Immunology, Division of Clinical Pathology, University and University Hospitals of Geneva, 1211 Geneva, Switzerland.

9. IRCCS San Raffaele Scientific Institute, 20132 Milan, Italy.

10. Institute for Virology, OE5230, Hannover Medical School, Carl-Neuberg-Str. 1, 30625 Hannover, Germany.

11. Department of Dermatology, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland.

12. Institute of Inflammation and Ageing, University of Birmingham, Birmingham, UK.

13. Institute of Pathology, University of Bern, 3008 Bern, Switzerland.

14. Institució Catalana de Recerca i Estudis Avançats (ICREA), Pg. Lluis Companys 23, 08010 Barcelona, Spain.

Abstract

Salivary gland memory CD8 + T cells use distinct motility modes and cooperate with tissue macrophages for organ surveillance.

Funder

Swiss National Science Foundation

Publisher

American Association for the Advancement of Science (AAAS)

Subject

General Medicine,Immunology

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