Human CD4 + CD103 + cutaneous resident memory T cells are found in the circulation of healthy individuals

Author:

Klicznik Maria M.1ORCID,Morawski Peter A.2ORCID,Höllbacher Barbara12ORCID,Varkhande Suraj R.1ORCID,Motley Samantha J.2ORCID,Kuri-Cervantes Leticia3ORCID,Goodwin Eileen3,Rosenblum Michael D.4ORCID,Long S. Alice2ORCID,Brachtl Gabriele5,Duhen Thomas2,Betts Michael R.3,Campbell Daniel J.26ORCID,Gratz Iris K.127ORCID

Affiliation:

1. Department of Biosciences, University of Salzburg, Salzburg, Austria.

2. Benaroya Research Institute, Seattle, WA 98101, USA.

3. Department of Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.

4. Department of Dermatology, University of California, San Francisco, San Francisco, CA 94143, USA.

5. Experimental and Clinical Cell Therapy Institute, Spinal Cord and Tissue Regeneration Center, Paracelsus Medical University, Salzburg, Austria.

6. Department of Immunology, University of Washington School of Medicine, Seattle, WA 98109, USA.

7. EB House Austria, Department of Dermatology, University Hospital of the Paracelsus Medical University, Salzburg, Austria.

Abstract

Human blood and lymph contain circulating CD4 + CD103 + cutaneous resident memory T cells that can seed distant skin sites. See the related Focus by Carbone and Gebhardt .

Funder

National Institute of Allergy and Infectious Diseases

Austrian Academy of Sciences

FWF

University of Salzburg

Publisher

American Association for the Advancement of Science (AAAS)

Subject

General Medicine,Immunology

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