Type 3 cytokines IL-17A and IL-22 drive TGF-β–dependent liver fibrosis-Reference-Cited by-同舟云学术

Type 3 cytokines IL-17A and IL-22 drive TGF-β–dependent liver fibrosis

Published:2018-10-26 Issue:28 Volume:3 Page:
ISSN:2470-9468
Container-title:Science Immunology
language:en
Short-container-title:Sci. Immunol.

Author:

Fabre Thomas¹²^ORCID,Molina Manuel Flores¹²^ORCID,Soucy Geneviève¹³,Goulet Jean-Philippe⁴,Willems Bernard¹⁵,Villeneuve Jean-Pierre¹⁵,Bilodeau Marc¹⁵^ORCID,Shoukry Naglaa H.¹⁵^ORCID

Affiliation:

1. Centre de Recherche du Centre hospitalier de l’Université de Montréal (CRCHUM), Montréal, Québec, Canada.

2. Département de microbiologie, infectiologie et immunologie, Faculté de médecine, Université de Montréal, Montréal, Québec, Canada.

3. Département de pathologie et biologie cellulaire, Faculté de médecine, Université de Montréal, Montréal, Québec, Canada.

4. Caprion, Montréal, Québec, Canada.

5. Département de médecine, Faculté de médecine, Université de Montréal, Montréal, Québec, Canada.

Abstract

Type 3 immune response defined by increased IL-22 production drives fibrosis during chronic liver injury via enhanced TGF-β signaling.

Funder

Canadian Institutes of Health Research

Fonds de Recherche du Québec - Santé

Canadian Liver Foundation

Fonds de recherche du Québec – Santé (FRQS) AIDS and Infectious Disease Network

Canadian Network on Hepatitis C

Novartis/Canadian Liver Foundation Hepatology Research Chair

Publisher

American Association for the Advancement of Science (AAAS)

Subject

General Medicine,Immunology

Reference51 articles.

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