Association of HLA-dependent islet autoimmunity with systemic antibody responses to intestinal commensal bacteria in children-Reference-Cited by-同舟云学术

Association of HLA-dependent islet autoimmunity with systemic antibody responses to intestinal commensal bacteria in children

Published:2019-02-08 Issue:32 Volume:4 Page:
ISSN:2470-9468
Container-title:Science Immunology
language:en
Short-container-title:Sci. Immunol.

Author:

Paun Alexandra¹²,Yau Christopher¹²^ORCID,Meshkibaf Shahab¹,Daigneault Michelle C.³^ORCID,Marandi Leili⁴,Mortin-Toth Steven¹^ORCID,Bar-Or Amit⁵⁶,Allen-Vercoe Emma³^ORCID,Poussier Philippe²⁴,Danska Jayne S.¹²⁷^ORCID

Affiliation:

1. Hospital for Sick Children, Toronto, ON, Canada.

2. Department of Immunology, University of Toronto, Faculty of Medicine, Toronto, ON, Canada.

3. Department of Molecular and Cellular Biology, University of Guelph, Guelph, ON, Canada.

4. Sunnybrook Research Institute, Toronto, ON Canada.

5. Montreal Neurological Institute, McGill University, Montreal, QC, Canada.

6. Department of Neurology, Perelman Center for Advanced Medicine, University of Pennsylvania School of Medicine, Philadelphia, PA, U.S.A.

7. Department of Medical Biophysics, University of Toronto, Faculty of Medicine, Toronto, ON, Canada.

Abstract

Immune responses to gut bacteria display HLA- dependent associations with progression to type 1 diabetes.

Funder

Juvenile Diabetes Research Foundation

Juvenile Diabetes Research Foundation Canada

Canadian Institutes of Health Research

Hospital for Sick Children

National Science and Engineering Council of Canada

Publisher

American Association for the Advancement of Science (AAAS)

Subject

General Medicine,Immunology

Reference50 articles.

1. The hygiene hypothesis in autoimmunity: the role of pathogens and commensals

2. The intestinal microbiome in spondyloarthritis

3. The microbiome and rheumatoid arthritis

4. The Dynamics of the Human Infant Gut Microbiome in Development and in Progression toward Type 1 Diabetes

5. Phenome-wide scanning identifies multiple diseases and disease severity phenotypes associated with HLA variants

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