Deep immune profiling of MIS-C demonstrates marked but transient immune activation compared with adult and pediatric COVID-19-Reference-Cited by-同舟云学术

Deep immune profiling of MIS-C demonstrates marked but transient immune activation compared with adult and pediatric COVID-19

Published:2021-03-04 Issue:57 Volume:6 Page:
ISSN:2470-9468
Container-title:Science Immunology
language:en
Short-container-title:Sci. Immunol.

Author:

Vella Laura A.¹²,Giles Josephine R.²³⁴^ORCID,Baxter Amy E.²³^ORCID,Oldridge Derek A.²⁵⁶^ORCID,Diorio Caroline⁷⁸^ORCID,Kuri-Cervantes Leticia²⁹^ORCID,Alanio Cécile²³⁴^ORCID,Pampena Maria Betina²⁹^ORCID,Wu Jennifer E.²³⁴^ORCID,Chen Zeyu²³,Huang Yinghui Jane²³^ORCID,Anderson Elizabeth M.²⁹^ORCID,Gouma Sigrid²⁹^ORCID,McNerney Kevin O.⁷⁸^ORCID,Chase Julie⁷¹⁰^ORCID,Burudpakdee Chakkapong⁷,Lee Jessica H.⁷,Apostolidis Sokratis A.²¹¹^ORCID,Huang Alexander C.²¹²,Mathew Divij²³^ORCID,Kuthuru Oliva²³^ORCID,Goodwin Eileen C.²⁹,Weirick Madison E.²⁹^ORCID,Bolton Marcus J.²⁹^ORCID,Arevalo Claudia P.²⁹^ORCID,Ramos Andre²³,Jasen C. J.¹³^ORCID,Conrey Peyton E.¹³^ORCID,Sayed Samir¹³^ORCID,Giannini Heather M.¹⁴^ORCID,D’Andrea Kurt¹⁵^ORCID,Meyer Nuala J.¹⁴^ORCID,Behrens Edward M.²⁷¹⁰^ORCID,Bassiri Hamid¹²⁷^ORCID,Hensley Scott E.²⁹^ORCID,Henrickson Sarah E.²⁷⁹¹³^ORCID,Teachey David T.⁷⁸^ORCID,Betts Michael R.²⁹^ORCID,Wherry E. John²³⁴^ORCID,Adamski Sharon,Alam Zahidul,Addison Mary M.,Byrne Katelyn T.,Chandra Aditi,Descamps Hélène C.,Han Nicholas,Kaminskiy Yaroslav,Kammerman Shane C.,Kim Justin,Greenplate Allison R.,Hamilton Jacob T.,Markosyan Nune,Noll Julia Han,Omran Dalia K.,Pattekar Ajinkya,Perkey Eric,Prager Elizabeth M.,Pueschl Dana,Rennels Austin,Shah Jennifer B.,Shilan Jake S.,Wellhausen Nils,Vanderbeck Ashley N.,

Affiliation:

1. Division of Infectious Diseases, Department of Pediatrics, Children’s Hospital of Philadelphia, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA 19104, USA.

2. Institute for Immunology, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA 19104, USA.

3. Department of Systems Pharmacology and Translational Therapeutics, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA 19104, USA.

4. Parker Institute for Cancer Immunotherapy, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA 19104, USA.

5. Department of Pathology and Laboratory Medicine, Children's Hospital of Philadelphia, Philadelphia, PA 19104, USA.

6. Department of Pathology and Laboratory Medicine, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA 19104, USA.

7. Immune Dysregulation Frontier Program, Department of Pediatrics, Children’s Hospital of Philadelphia, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA 19104, USA.

8. Division of Oncology, Department of Pediatrics, Children’s Hospital of Philadelphia, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA 19104, USA.

9. Department of Microbiology, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA 19104, USA.

10. Division of Rheumatology, Department of Pediatrics, Children’s Hospital of Philadelphia, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA 19104, USA.

11. Division of Rheumatology, Department of Medicine, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA 19104, USA.

12. Division of Hematology and Oncology, Department of Medicine, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA 19104, USA.

13. Division of Allergy and Immunology, Department of Pediatrics, Children’s Hospital of Philadelphia, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA 19104, USA.

14. Division of Pulmonary and Critical Care Medicine, Department of Medicine, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA 19104, USA.

15. Division of Translational Medicine and Human Genetics, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA 19104, USA.

Abstract

MIS-C is defined by lymphocyte activation, including elevated plasmablast frequencies and marked activation of CX3CR1 + CD8 + T cells.

Funder

National Institutes of Health

National Heart, Lung, and Blood Institute

National Institute of Allergy and Infectious Diseases

National Cancer Institute

The Parker Foundation

Mark Foundation For Cancer Research

University of Pennsylvania Institute for Immunology Glick

Paul G. Allen Frontiers Group

Children's Hospital of Philadelphia

Elektrobit

Högskolan i Borås

Classical Association

Parker Institute for Cancer Immunotherapy

Publisher

American Association for the Advancement of Science (AAAS)

Subject

General Medicine,Immunology

Reference80 articles.

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5. SARS-CoV-2–Associated Deaths Among Persons Aged <21 Years — United States, February 12–July 31, 2020

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