Clever-1 contributes to lymphocyte entry into the spleen via the red pulp

Author:

Tadayon Sina1ORCID,Dunkel Johannes1ORCID,Takeda Akira1ORCID,Halle Olga2,Karikoski Marika1,Gerke Heidi1,Rantakari Pia1ORCID,Virtakoivu Reetta1ORCID,Pabst Oliver3,Salmi Marko1,Hollmén Maija1ORCID,Jalkanen Sirpa1

Affiliation:

1. MediCity Research Laboratory and Institute of Biomedicine, University of Turku, 20520 Turku, Finland.

2. Institute of Immunology, Hannover Medical School, 30625 Hannover, Germany.

3. Institute of Molecular Medicine, RWTH Aachen University, 52074 Aachen, Germany.

Abstract

Lymphocyte entry into the spleen is initiated by their binding to Clever-1–expressing vessels in the red pulp.

Funder

Deutsche Forschungsgemeinschaft

Suomen Akatemia

Sigrid Juséliuksen Säätiö

Syöpäjärjestöt

Sigrid Juselius Foundation

Publisher

American Association for the Advancement of Science (AAAS)

Subject

General Medicine,Immunology

Reference42 articles.

1. The role of the spleen in resistance to infection;Bohnsack J. F.;Annu. Rev. Med.,1986

2. Human spleen microanatomy: why mice do not suffice

3. The strict regulation of lymphocyte migration to splenic white pulp does not involve common homing receptors;Nolte M. A.;Immunology,2002

4. Expression of the mucosal vascular addressin, MAdCAM-1, on sinus-lining cells in the spleen;Kraal G.;Am. J. Pathol.,1995

5. Absolute numbers of lymphocytes subsets migrating through the compartments of the normal and transplanted rat spleen;Willführ K. U.;Eur. J. Immunol.,1990

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