Cytidine deaminase 2 is required for VLRB antibody gene assembly in lampreys-Reference-Cited by-同舟云学术

Cytidine deaminase 2 is required for VLRB antibody gene assembly in lampreys

Published:2020-03-13 Issue:45 Volume:5 Page:
ISSN:2470-9468
Container-title:Science Immunology
language:en
Short-container-title:Sci. Immunol.

Author:

Morimoto Ryo¹^ORCID,O’Meara Connor P.¹,Holland Stephen J.¹,Trancoso Inês¹^ORCID,Souissi Ahmed²^ORCID,Schorpp Michael¹^ORCID,Vassaux Danièle²,Iwanami Norimasa¹^ORCID,Giorgetti Orlando B.¹,Evanno Guillaume²,Boehm Thomas¹^ORCID

Affiliation:

1. Department of Developmental Immunology, Max Planck Institute of Immunobiology and Epigenetics, 79108 Freiburg, Germany.

2. ESE, Ecology and Ecosystems Health, INRAE, Agrocampus Ouest, 35042 Rennes, France.

Abstract

Functional assembly of lamprey antibody genes depends on CDA2 , a gene related to mammalian activation-induced cytidine deaminase, AID.

Funder

European Research Council

Max Planck Institute of Immunobiology and Epigenetics

Jung Foundation for Science and Research

Publisher

American Association for the Advancement of Science (AAAS)

Subject

General Medicine,Immunology

Reference34 articles.

1. Origin and Evolution of Adaptive Immunity

2. Facts and fancies about early fossil chordates and vertebrates

3. Evolution of the Immune System in the Lower Vertebrates

4. Dual nature of the adaptive immune system in lampreys

5. Evolutionary implications of a third lymphocyte lineage in lampreys

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