Defects in LC3B2 and ATG4A underlie HSV2 meningitis and reveal a critical role for autophagy in antiviral defense in humans-Reference-Cited by-同舟云学术

Defects in LC3B2 and ATG4A underlie HSV2 meningitis and reveal a critical role for autophagy in antiviral defense in humans

Published:2020-12-18 Issue:54 Volume:5 Page:
ISSN:2470-9468
Container-title:Science Immunology
language:en
Short-container-title:Sci. Immunol.

Author:

Hait Alon Schneider¹²^ORCID,Olagnier David²^ORCID,Sancho-Shimizu Vanessa³^ORCID,Skipper Kristian Alsbjerg²^ORCID,Helleberg Marie⁴^ORCID,Larsen Simon Muller¹^ORCID,Bodda Chiranjeevi²,Moldovan Liviu Ionut⁵,Ren Fanghui²,Brinck Andersen Nanna-Sophie¹²,Thomsen Michelle M.¹²^ORCID,Freytag Mette Ratzer¹²,Darmalinggam Sathya³^ORCID,Parkes Isobel³^ORCID,Kadekar Darshana D.²,Rahbek Stine Hess²,van der Horst Demi²^ORCID,Kristensen Lasse Sommer²⁵^ORCID,Eriksson Kristina⁶^ORCID,Kjems Jørgen⁵,Mostowy Serge⁷^ORCID,Christiansen Mette⁸^ORCID,Mikkelsen Jacob Giehm²^ORCID,Brandt Christian Thomas⁹,Paludan Søren R.²⁶^ORCID,Mogensen Trine H.¹²¹⁰^ORCID

Affiliation:

1. Department of Infectious Diseases, Aarhus University Hospital, Aarhus, Denmark.

2. Department of Biomedicine, Faculty of Health, Aarhus University, Aarhus, Denmark.

3. Faculty of Medicine, Department of Infectious Disease, Section of Pediatric Infectious Disease, Imperial Collage London, London, UK.

4. Department of Infectious Diseases, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark.

5. iNano, Department of Molecular Biology and Genetics, Aarhus University, Aarhus, Denmark.

6. Department of Rheumatology and Inflammation Research, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.

7. Department of Infection Biology, Faculty of Infectious and Tropical Diseases, London School of Hygiene & Tropical Medicine, London, UK.

8. Department of Molecular Medicine, Aarhus University Hospital, Aarhus, Denmark.

9. Department of Infectious Diseases, Institute of Clinical Medicine, North Zealands Hospital, Hillerød, Denmark.

10. Department of Clinical Medicine, Aarhus University, Aarhus, Denmark.

Abstract

Autophagy defects predispose to recurrent HSV2 meningitis and reveal an important role for autophagy in antiviral immunity.

Funder

European Research Council

Aarhus Universitets Forskningsfond

Lundbeckfonden

Novo Nordisk Fonden

Independent Researh Fund Denmark

Publisher

American Association for the Advancement of Science (AAAS)

Subject

General Medicine,Immunology

Reference63 articles.

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