Timing and location dictate monocyte fate and their transition to tumor-associated macrophages-Reference-Cited by-同舟云学术

Timing and location dictate monocyte fate and their transition to tumor-associated macrophages

Published:2024-07-26 Issue:97 Volume:9 Page:
ISSN:2470-9468
Container-title:Science Immunology
language:en
Short-container-title:Sci. Immunol.

Author:

Dunsmore Garett¹²^ORCID,Guo Wei³^ORCID,Li Ziyi³,Bejarano David Alejandro⁴^ORCID,Pai Rhea⁵,Yang Katharine⁶^ORCID,Kwok Immanuel⁶^ORCID,Tan Leonard⁶^ORCID,Ng Melissa⁶^ORCID,De La Calle Fabregat Carlos¹^ORCID,Yatim Aline⁷,Bougouin Antoine⁸,Mulder Kevin¹²^ORCID,Thomas Jake⁴^ORCID,Villar Javiera¹^ORCID,Bied Mathilde¹²,Kloeckner Benoit¹²^ORCID,Dutertre Charles-Antoine¹^ORCID,Gessain Grégoire¹^ORCID,Chakarov Svetoslav³^ORCID,Liu Zhaoyuan³^ORCID,Scoazec Jean-Yves¹^ORCID,Lennon-Dumenil Ana-Maria⁷^ORCID,Marichal Thomas⁹¹⁰¹¹^ORCID,Sautès-Fridman Catherine⁸,Fridman Wolf Herman⁸^ORCID,Sharma Ankur⁵¹²¹³¹⁴¹⁵^ORCID,Su Bing³^ORCID,Schlitzer Andreas⁴,Ng Lai Guan¹⁶¹⁷^ORCID,Blériot Camille¹¹⁸^ORCID,Ginhoux Florent¹²³⁶¹⁹^ORCID

Affiliation:

1. Institut Gustave Roussy, INSERM U1015, Bâtiment de Médecine Moléculaire 114 rue Edouard Vaillant, 94800 Villejuif, France.

2. Université Paris-Saclay, Ile-de-France, France.

3. Shanghai Institute of Immunology, Department of Immunology and Microbiology, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China.

4. Quantitative Systems Biology, Life and Medical Sciences Institute, University of Bonn, 53115 Bonn, Germany.

5. Curtin Medical School, Curtin University, Bentley, WA, Australia.

6. Singapore Immunology Network (SIgN), A*STAR, 8A Biomedical Grove, Immunos Building, Level 3, Singapore 138648, Singapore.

7. Institut Curie, PSL University, INSERM U932, Immunity and Cancer, 75005 Paris, France.

8. Centre de Recherche des Cordeliers, INSERM, Sorbonne Université, USPC Université Paris Cité, Equipe Labellisée Ligue Nationale Contre le Cancer, Paris, France.

9. Laboratory of Immunophysiology, GIGA Institute, Liège University, Liège, Belgium.

10. Faculty of Veterinary Medicine, Liège University, Liège, Belgium.

11. Walloon Excellence in Life Sciences and Biotechnology (WELBIO) Department, WEL Research Institute, Wavre, Belgium.

12. Harry Perkins Institute of Medical Research, QEII Medical Centre and Centre for Medical Research, 6 Verdun Street, Nedlands, Perth, WA 6009, Australia.

13. Institute of Molecular and Cellular Biology, A*STAR, Singapore 138673, Singapore.

14. KK Research Centre, KK Women’s and Children’s Hospital, Singapore 229899, Singapore.

15. Translational Genomics Program, Garvan Institute of Medical Research and Kinghorn Cancer Centre, Darlinghurst, NSW, Australia.

16. Shanghai Immune Therapy Institute Renji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200010, China.

17. Department of Microbiology and Immunology, National University of Singapore, Singapore, Singapore.

18. Institut Necker Enfants Malades (INEM), CNRS UMR 8253, INSERM U1151, 160 rue de Vaugirard, 75015 Paris, France.

19. Department of Medicine, Yong Loo Lin School of Medicine, National University of Singapore, Singapore 119228 Singapore.

Abstract

Tumor-associated macrophages (TAMs) are a heterogeneous population of cells whose phenotypes and functions are shaped by factors that are incompletely understood. Herein, we asked when and where TAMs arise from blood monocytes and how they evolve during tumor development. We initiated pancreatic ductal adenocarcinoma (PDAC) in inducible monocyte fate-mapping mice and combined single-cell transcriptomics and high-dimensional flow cytometry to profile the monocyte-to-TAM transition. We revealed that monocytes differentiate first into a transient intermediate population of TAMs that generates two longer-lived lineages of terminally differentiated TAMs with distinct gene expression profiles, phenotypes, and intratumoral localization. Transcriptome datasets and tumor samples from patients with PDAC evidenced parallel TAM populations in humans and their prognostic associations. These insights will support the design of new therapeutic strategies targeting TAMs in PDAC.

Publisher

American Association for the Advancement of Science (AAAS)

Link

https://www.science.org/doi/pdf/10.1126/sciimmunol.adk3981

Reference63 articles.

1. Involvement of PD-L1 on tumor cells in the escape from host immune system and tumor immunotherapy by PD-L1 blockade

2. Enhancement of Antitumor Immunity by CTLA-4 Blockade

3. Nivolumab in Previously Untreated Melanoma withoutBRAFMutation

4. Pancreatic cancer and immune checkpoint inhibitors—still a long way to go

5. Macrophages in health and disease

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