The AIM2 and NLRP3 inflammasomes trigger IL-1–mediated antitumor effects during radiation-Reference-Cited by-同舟云学术

The AIM2 and NLRP3 inflammasomes trigger IL-1–mediated antitumor effects during radiation

Published:2021-05-28 Issue:59 Volume:6 Page:
ISSN:2470-9468
Container-title:Science Immunology
language:en
Short-container-title:Sci. Immunol.

Author:

Han Chuanhui¹^ORCID,Godfrey Victoria¹^ORCID,Liu Zhida¹^ORCID,Han Yanfei²^ORCID,Liu Longchao¹^ORCID,Peng Hua²^ORCID,Weichselbaum Ralph R.³^ORCID,Zaki Hasan¹^ORCID,Fu Yang-Xin¹^ORCID

Affiliation:

1. Department of Pathology, UT Southwestern Medical Center, Dallas, TX, USA.

2. Institute of Biophysics, Chinese Academy of Sciences. Beijing, China.

3. Department of Radiation and Cellular Oncology and Ludwig Center for Metastasis Research, University of Chicago, Chicago, IL, USA.

Abstract

Radiation activates AIM2 and NLRP3 inflammasomes to enhance IL-1 signaling on DCs, leading to antitumor immunity.

Funder

National Institute of Diabetes and Digestive and Kidney Diseases

Cancer Prevention and Research Institute of Texas

Publisher

American Association for the Advancement of Science (AAAS)

Subject

General Medicine,Immunology

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