Oral epithelial cells orchestrate innate type 17 responses to Candida albicans through the virulence factor candidalysin

Author:

Verma Akash H.1ORCID,Richardson Jonathan P.2,Zhou Chunsheng1ORCID,Coleman Bianca M.1ORCID,Moyes David L.23ORCID,Ho Jemima2ORCID,Huppler Anna R.4,Ramani Kritika1,McGeachy Mandy J.1,Mufazalov Ilgiz A.5ORCID,Waisman Ari5ORCID,Kane Lawrence P.6ORCID,Biswas Partha S.1,Hube Bernhard789ORCID,Naglik Julian R.2ORCID,Gaffen Sarah L.1ORCID

Affiliation:

1. Division of Rheumatology and Clinical Immunology, University of Pittsburgh, Pittsburgh, PA 15261, USA.

2. Mucosal and Salivary Biology Division, Dental Institute, King’s College London, London, UK.

3. Centre for Host-Microbiome Interactions, Mucosal and Salivary Biology Division, Dental Institute, King’s College London, London, UK.

4. Department of Pediatrics, Children’s Research Institute, Children’s Hospital and Health System, Medical College of Wisconsin, Milwaukee, WI 53226, USA.

5. Institute for Molecular Medicine, University Medical Center of the Johannes Gutenberg University of Mainz, Mainz, Germany.

6. Department of Immunology, University of Pittsburgh, Pittsburgh, PA 15261, USA.

7. Department of Microbial Pathogenicity Mechanisms, Leibniz Institute for Natural Product Research and Infection Biology–Hans Knoell Institute, Jena, Germany.

8. Friedrich-Schiller University, Jena, Germany.

9. Center for Sepsis Control and Care, Jena University Hospital, Jena, Germany.

Abstract

Candidalysin, a hypha-associated fungal peptide, drives interleukin-17 responses to Candida albicans .

Funder

National Institute of Allergy and Infectious Diseases

National Institute of Diabetes and Digestive and Kidney Diseases

National Institute of Dental and Craniofacial Research

Medical Research Council

Biotechnology and Biological Sciences Research Council

Publisher

American Association for the Advancement of Science (AAAS)

Subject

General Medicine,Immunology

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