Autoantibodies neutralizing type I IFNs are present in ~4% of uninfected individuals over 70 years old and account for ~20% of COVID-19 deaths-Reference-Cited by-同舟云学术

Autoantibodies neutralizing type I IFNs are present in ~4% of uninfected individuals over 70 years old and account for ~20% of COVID-19 deaths

Published:2021-08-10 Issue:62 Volume:6 Page:
ISSN:2470-9468
Container-title:Science Immunology
language:en
Short-container-title:Sci. Immunol.

Author:

Bastard Paul¹²³^ORCID,Gervais Adrian¹²^ORCID,Le Voyer Tom¹²^ORCID,Rosain Jérémie¹²^ORCID,Philippot Quentin¹²,Manry Jérémy¹²^ORCID,Michailidis Eleftherios⁴^ORCID,Hoffmann Hans-Heinrich⁴^ORCID,Eto Shohei⁵^ORCID,Garcia-Prat Marina⁶^ORCID,Bizien Lucy¹²^ORCID,Parra-Martínez Alba⁶^ORCID,Yang Rui³^ORCID,Haljasmägi Liis⁷^ORCID,Migaud Mélanie¹²^ORCID,Särekannu Karita⁷^ORCID,Maslovskaja Julia⁷,de Prost Nicolas⁸⁹^ORCID,Tandjaoui-Lambiotte Yacine¹⁰^ORCID,Luyt Charles-Edouard¹¹¹²^ORCID,Amador-Borrero Blanca¹³^ORCID,Gaudet Alexandre¹⁴¹⁵¹⁶¹⁷¹⁸,Poissy Julien¹⁴¹⁵¹⁶¹⁷¹⁸^ORCID,Morel Pascal¹⁹²⁰,Richard Pascale¹⁹^ORCID,Cognasse Fabrice²¹²²^ORCID,Troya Jesus²³^ORCID,Trouillet-Assant Sophie²⁴²⁵²⁶^ORCID,Belot Alexandre²⁴²⁵²⁷²⁸^ORCID,Saker Kahina²⁴²⁵^ORCID,Garçon Pierre²⁹,Rivière Jacques G.⁶^ORCID,Lagier Jean-Christophe³⁰³¹,Gentile Stéphanie³²³³^ORCID,Rosen Lindsey B.³⁴^ORCID,Shaw Elana³⁴^ORCID,Morio Tomohiro³⁵,Tanaka Junko³⁶,Dalmau David³⁷^ORCID,Tharaux Pierre-Louis³⁸^ORCID,Sene Damien¹³,Stepanian Alain³⁹^ORCID,Megarbane Bruno⁴⁰^ORCID,Triantafyllia Vasiliki⁴¹^ORCID,Fekkar Arnaud¹⁴²^ORCID,Heath James R.⁴³^ORCID,Franco José Luis⁴⁴^ORCID,Anaya Juan-Manuel⁴⁵^ORCID,Solé-Violán Jordi⁴⁶⁴⁷,Imberti Luisa⁴⁸^ORCID,Biondi Andrea⁴⁹,Bonfanti Paolo⁵⁰^ORCID,Castagnoli Riccardo³⁴⁵¹^ORCID,Delmonte Ottavia M.³⁴,Zhang Yu³⁴⁵²,Snow Andrew L.⁵³^ORCID,Holland Steven M.³⁴^ORCID,Biggs Catherine M.⁵⁴^ORCID,Moncada-Vélez Marcela³^ORCID,Arias Andrés Augusto³⁵⁵⁵⁶^ORCID,Lorenzo Lazaro¹²^ORCID,Boucherit Soraya¹²^ORCID,Coulibaly Boubacar¹²,Anglicheau Dany⁵⁷⁵⁸^ORCID,Planas Anna M.⁵⁹⁶⁰^ORCID,Haerynck Filomeen⁶¹^ORCID,Duvlis Sotirija⁶²⁶³^ORCID,Nussbaum Robert L.⁶⁴^ORCID,Ozcelik Tayfun⁶⁵,Keles Sevgi⁶⁶,Bousfiha Ahmed A.⁶⁷^ORCID,El Bakkouri Jalila⁶⁷^ORCID,Ramirez-Santana Carolina⁴⁴⁴⁵^ORCID,Paul Stéphane⁶⁸^ORCID,Pan-Hammarström Qiang⁶⁹^ORCID,Hammarström Lennart⁶⁹^ORCID,Dupont Annabelle⁷⁰^ORCID,Kurolap Alina⁷¹^ORCID,Metz Christine N.⁷²^ORCID,Aiuti Alessandro⁷³^ORCID,Casari Giorgio⁷³^ORCID,Lampasona Vito⁷⁴^ORCID,Ciceri Fabio⁷⁵^ORCID,Barreiros Lucila A.⁷⁶^ORCID,Dominguez-Garrido Elena⁷⁷^ORCID,Vidigal Mateus⁷⁸^ORCID,Zatz Mayana⁷⁸^ORCID,van de Beek Diederik⁷⁹^ORCID,Sahanic Sabina⁸⁰,Tancevski Ivan⁸⁰,Stepanovskyy Yurii⁸¹^ORCID,Boyarchuk Oksana⁸²^ORCID,Nukui Yoko⁸³^ORCID,Tsumura Miyuki⁵,Vidaur Loreto⁸⁴⁸⁵^ORCID,Tangye Stuart G.⁸⁶⁸⁷^ORCID,Burrel Sonia⁸⁸^ORCID,Duffy Darragh⁸⁹^ORCID,Quintana-Murci Lluis⁹⁰⁹¹^ORCID,Klocperk Adam⁹²^ORCID,Kann Nelli Y.⁹³^ORCID,Shcherbina Anna⁹³^ORCID,Lau Yu-Lung⁹⁴^ORCID,Leung Daniel⁹⁴^ORCID,Coulongeat Matthieu⁹⁵^ORCID,Marlet Julien⁹⁶⁹⁷^ORCID,Koning Rutger⁷⁹^ORCID,Reyes Luis Felipe⁹⁸⁹⁹^ORCID,Chauvineau-Grenier Angélique¹⁰⁰,Venet Fabienne¹⁰¹¹⁰²¹⁰³^ORCID,Monneret Guillaume¹⁰¹¹⁰³^ORCID,Nussenzweig Michel C.¹⁰⁴¹⁰⁵^ORCID,Arrestier Romain⁸⁹,Boudhabhay Idris⁵⁷⁵⁸,Baris-Feldman Hagit⁷¹¹⁰⁶^ORCID,Hagin David¹⁰⁶¹⁰⁷^ORCID,Wauters Joost¹⁰⁸^ORCID,Meyts Isabelle¹⁰⁹¹¹⁰^ORCID,Dyer Adam H.¹¹¹¹¹²^ORCID,Kennelly Sean P.¹¹¹¹¹²,Bourke Nollaig M.¹¹²^ORCID,Halwani Rabih¹¹³^ORCID,Sharif-Askari Narjes Saheb¹¹³^ORCID,Dorgham Karim¹¹⁴^ORCID,Sallette Jérome¹¹⁵,Mehlal Sedkaoui Souad¹¹⁵,AlKhater Suzan¹¹⁶¹¹⁷^ORCID,Rigo-Bonnin Raúl¹¹⁸^ORCID,Morandeira Francisco¹¹⁹,Roussel Lucie¹²⁰¹²¹^ORCID,Vinh Donald C.¹²⁰¹²¹^ORCID,Ostrowski Sisse Rye¹²²^ORCID,Condino-Neto Antonio⁷⁶^ORCID,Prando Carolina¹²³^ORCID,Bondarenko Anastasiia⁸¹,Spaan András N.³¹²⁴^ORCID,Gilardin Laurent¹²⁵¹²⁶^ORCID,Fellay Jacques¹²⁷¹²⁸¹²⁹^ORCID,Lyonnet Stanislas¹³⁰,Bilguvar Kaya¹³¹¹³²¹³³¹³⁴^ORCID,Lifton Richard P.¹³¹¹³²¹³⁵,Mane Shrikant¹³²^ORCID,Anderson Mark S.¹³⁶^ORCID,Boisson Bertrand¹²³^ORCID,Béziat Vivien¹²³^ORCID,Zhang Shen-Ying¹²³,Andreakos Evangelos⁴¹^ORCID,Hermine Olivier²¹³⁷^ORCID,Pujol Aurora¹³⁸^ORCID,Peterson Pärt⁷^ORCID,Mogensen Trine H.¹³⁹¹⁴⁰^ORCID,Rowen Lee⁴³,Mond James¹⁴¹,Debette Stéphanie¹⁴²¹⁴³,de Lamballerie Xavier¹⁴⁴^ORCID,Duval Xavier¹⁴⁵¹⁴⁶¹⁴⁷¹⁴⁸,Mentré France¹⁴⁵¹⁴⁶¹⁴⁷,Zins Marie¹⁴⁹^ORCID,Soler-Palacin Pere⁶^ORCID,Colobran Roger¹⁵⁰^ORCID,Gorochov Guy¹¹⁴¹⁵¹^ORCID,Solanich Xavier¹⁵²^ORCID,Susen Sophie⁷⁰^ORCID,Martinez-Picado Javier¹⁵³¹⁵⁴¹⁵⁵^ORCID,Raoult Didier³⁰³¹,Vasse Marc¹⁵⁶,Gregersen Peter K.⁷²^ORCID,Piemonti Lorenzo⁷⁴^ORCID,Rodríguez-Gallego Carlos¹⁵⁷¹⁵⁸^ORCID,Notarangelo Luigi D.³⁴^ORCID,Su Helen C.³⁴¹⁵⁹^ORCID,Kisand Kai⁷^ORCID,Okada Satoshi⁵^ORCID,Puel Anne¹²³^ORCID,Jouanguy Emmanuelle¹²³^ORCID,Rice Charles M.⁴,Tiberghien Pierre¹⁹²⁰^ORCID,Zhang Qian¹²³^ORCID,Cobat Aurélie¹²³^ORCID,Abel Laurent¹²³^ORCID,Casanova Jean-Laurent¹²³¹⁰⁵^ORCID,Bigio Benedetta,Boucherit Soraya,de la Chapelle Aliénor,Chen Jie,Chrabieh Maya,Coulibaly Boubacar,Liu Dana,Nemirowskaya Yelena,Cruz Inés Marín,Materna Marie,Pelet Sophie,Seeleuthner Yoann,Thibault Chloé,Liu Zhiyong,Abad Jorge,Accordino Giulia,Achille Cristian,Aguilera-Albesa Sergio,Aguiló-Cucurull Aina,Aiuti Alessandro,Özkan Esra Akyüz,Darazam Ilad Alavi,Roblero Albisures Jonathan Antonio,Aldave Juan C,Ramos Miquel Alfonso,Khan Taj Ali,Aliberti Anna,Nadji Seyed Alireza,Alkan Gulsum,Alkhater Suzan A.,Allardet-Servent Jerome,Allende Luis M,Alonso-Arias Rebeca,Alshahrani Mohammed S,Alsina Laia,Alyanakian Marie-Alexandra,Borrero Blanca Amador,Amoura Zahir,Antolí Arnau,Arrestier Romain,Aubart Mélodie,Auguet Teresa,Avramenko Iryna,Aytekin Gökhan,Azot Axelle,Bahram Seiamak,Bajolle Fanny,Baldanti Fausto,Baldolli Aurélie,Ballester Maite,Feldman Hagit Baris,Barrou Benoit,Barzagh Federica,Basso Sabrina,Bayhan Gulsum Iclal,Belot Alexandre,Bezrodnik Liliana,Bilbao Agurtzane,Blanchard-Rohner Geraldine,Blanco Ignacio,Blandinières Adeline,Blázquez-Gamero Daniel,Bleibtreu Alexandre,Bloomfield Marketa,Bolivar-Prados Mireia,Bondarenko Anastasiia,Borghesi Alessandro,Borie Raphael,Botdhlo-Nevers Elisabeth,Bousfiha Ahmed A,Bousquet Aurore,Boutolleau David,Bouvattier Claire,Boyarchuk Oksana,Bravais Juliette,Briones M. Luisa,Brunner Marie-Eve,Bruno Raffaele,Bueno Maria Rita P,Bukhari Huda,Bustamante Jacinta,Cáceres Agra Juan José,Capra Ruggero,Carapito Raphael,Carrabba Maria,Casari Giorgio,Casasnovas Carlos,Caseris Marion,Cassaniti Irene,Castelle Martin,Castelli Francesco,de Vera Martín Castillo,Castro Mateus V,Catherinot Emilie,Celik Jale Bengi,Ceschi Alessandro,Chalumeau Martin,Charbit Bruno,Cheng Matthew P.,Clavé Père,Clotet Bonaventura,Codina Anna,Cohen Yves,Colobran Roger,Comarmond Cloé,Combes Alain,Comoli Patrizia,Corsico Angelo G,Coşkuner Taner,Cvetkovski Aleksandar,Cyrus Cyril,Dalmau David,Danion François,Darley David Ross,Das Vincent,Dauby Nicolas,Dauger Stéphane,De Munter Paul,de Pontual Loic,Dehban Amin,Delplancq Geoffroy,Demoule Alexandre,Desguerre Isabelle,Di Sabatino Antonio,Diehl Jean-Luc,Dobbelaere Stephanie,Domínguez-Garrido Elena,Dubost Clément,Ekwall Olov,Bozdemir Şefika Elmas,Elnagdy Marwa H,Emiroglu Melike,Endo Akifumi,Erdeniz Emine Hafize,Aytekin Selma Erol,Lasa Maria Pilar Etxart,Euvrard Romain,Fabio Giovanna,Faivre Laurence,Falck Antonin,Fartoukh Muriel,Faure Morgane,Arquero Miguel Fernandez,Ferrer Ricard,Ferreres Jose,Flores Carlos,Francois Bruno,Fumadó Victoria,Fung Kitty S C,Fusco Francesca,Gagro Alenka,Solis Blanca Garcia,Gaussem Pascale,Gayretli Zeynep,Gil-Herrera Juana,Gilardin Laurent,Gatineau Audrey Giraud,Girona-Alarcón Mònica,Cifuentes Godínez Karen Alejandra,Goffard Jean-Christophe,Gonzales Nacho,Gonzalez-Granado Luis I,González-Montelongo Rafaela,Guerder Antoine,Gülhan Belgin,Gumucio Victor Daniel,Hanitsch Leif Gunnar,Gunst Jan,Gut Marta,Hadjadj Jérôme,Haerynck Filomeen,Halwani Rabih,Hammarström Lennart,Hancerli Selda,Hariyan Tetyana,Hatipoglu Nevin,Heppekcan Deniz,Hernandez-Brito Elisa,Ho Po-ki,Holanda-Peña María Soledad,Horcajada Juan P,Hraiech Sami,Humbert Linda,Hung Ivan F N,Iglesias Alejandro D.,Íñigo-Campos Antonio,Jamme Matthieu,Arranz María Jesús,Jimeno Marie-Thérèse,Jordan Iolanda,Yüksek Saliha Kanık,Kara Yalcin Burak,Karahan Aydın,Karbuz Adem,Yasar Kadriye Kart,Kasapcopur Ozgur,Kashimada Kenichi,Keles Sevgi,Demirkol Yasemin Kendir,Kido Yasutoshi,Kizil Can,Kılıç Ahmet Osman,Klocperk Adam,Koutsoukou Antonia,Król Zbigniew J.,Ksouri Hatem,Kuentz Paul,Kwan Arthur M C,Kwan Yat Wah M,Kwok Janette S Y,Lagier Jean-Christophe,Lam David S Y,Lampropoulou Vicky,Lanternier Fanny,Lau Yu-Lung,Le Bourgeois Fleur,Leo Yee-Sin,Lopez Rafael Leon,Leung Daniel,Levin Michael,Levy Michael,Lévy Romain,Li Zhi,Lilleri Daniele,Lima Edson Jose Adrian Bolanos,Linglart Agnes,López-Collazo Eduardo,Lorenzo-Salazar José M.,Louapre Céline,Lubetzki Catherine,Lung Kwok-Cheung,Luyt Charles-Edouard,Lye David C,Magnone Cinthia,Mansouri Davood,Marchioni Enrico,Marioli Carola,Marjani Majid,Marques Laura,Pereira Jesus Marquez,Martín-Nalda Andrea,Pueyo David Martínez,Martinez-Picado Javier,Marzana Iciar,Mata-Martínez Carmen,Mathian Alexis,Matos Larissa RB,Matthews Gail V,Mayaux Julien,McLaughlin-Garcia Raquel,Meersseman Philippe,Mège Jean-Louis,Mekontso-Dessap Armand,Melki Isabelle,Meloni Federica,Meritet Jean-François,Merlani Paolo,Akcan Özge Metin,Meyts Isabelle,Mezidi Mehdi,Migeotte Isabelle,Millereux Maude,Million Matthieu,Mirault Tristan,Mircher Clotilde,Mirsaeidi Mehdi,Mizoguchi Yoko,Modi Bhavi P,Mojoli Francesco,Moncomble Elsa,Melián Abián Montesdeoca,Martinez Antonio Morales,Morandeira Francisco,Morange Pierre-Emmanuel,Mordacq Clémence,Morelle Guillaume,Mouly Stéphane J,Muñoz-Barrera Adrián,Nafati Cyril,Nagashima Shintaro,Nakagama Yu,Neven Bénédicte,Neves João Farela,Ng Lisa FP,Ng Yuk-Yung,Nielly Hubert,Medina Yeray Novoa,Cuadros Esmeralda Nuñez,Ocejo-Vinyals J. Gonzalo,Okamoto Keisuke,Oualha Mehdi,Ouedrani Amani,Özçelik Tayfun,Ozkaya-Parlakay Aslinur,Pagani Michele,Pan-Hammarström Qiang,Papadaki Maria,Parizot Christophe,Parola Philippe,Pascreau Tiffany,Paul Stéphane,Paz-Artal Estela,Pedraza Sigifredo,González Pellecer Nancy Carolina,Pellegrini Silvia,de Diego Rebeca Pérez,Pérez-Fernández Xosé Luis,Philippe Aurélien,Philippot Quentin,Picod Adrien,de Chambrun Marc Pineton,Piralla Antonio,Planas-Serra Laura,Ploin Dominique,Poissy Julien,Poncelet Géraldine,Poulakou Garyphallia,Pouletty Marie S,Pourshahnazari Persia,Qiu-Chen Jia Li,Quentric Paul,Rambaud Thomas,Raoult Didier,Raoult Violette,Rebillat Anne-Sophie,Redin Claire,Resmini Léa,Ricart Pilar,Richard Jean-Christophe,Rigo-Bonnin Raúl,Rivet Nadia,Rivière Jacques G,Rocamora-Blanch Gemma,Rodero Mathieu P,Rodrigo Carlos,Rodriguez Luis Antonio,Rodriguez-Gallego Carlos,Rodriguez-Palmero Agustí,Romero Carolina Soledad,Rothenbuhler Anya,Roux Damien,Rovina Nikoletta,Rozenberg Flore,Ruch Yvon,Ruiz Montse,Ruiz del Prado Maria Yolanda,Ruiz-Rodriguez Juan Carlos,Sabater-Riera Joan,Saks Kai,Salagianni Maria,Sanchez Oliver,Sánchez-Montalvá Adrián,Sánchez-Ramón Silvia,Schidlowski Laire,Schluter Agatha,Schmidt Julien,Schmidt Matthieu,Schuetz Catharina,Schweitzer Cyril E,Scolari Francesco,Sediva Anna,Seijo Luis,Seminario Analia Gisela,Sene Damien,Seng Piseth,Senoglu Sevtap,Seppänen Mikko,Llovich Alex Serra,Shahrooei Mohammad,Shcherbina Anna,Siguret Virginie,Siouti Eleni,Smadja David M,Smith Nikaia,Sobh Ali,Solanich Xavier,Solé-Violán Jordi,Soler Catherine,Soler-Palacín Pere,Sözeri Betül,Stella Giulia Maria,Stepanovskiy Yuriy,Stoclin Annabelle,Taccone Fabio,Tandjaoui-Lambiotte Yacine,Taupin Jean-Luc,Tavernier Simon J,Tello Loreto Vidaur,Terrier Benjamin,Thiery Guillaume,Thorball Christian,THORN Karolina,Thumerelle Caroline,Tipu Imran,Tolstrup Martin,Tomasoni Gabriele,Toubiana Julie,Alvarez Josep Trenado,Triantafyllia Vasiliki,Trouillet-Assant Sophie,Troya Jesús,Tsang Owen T Y,Tserel Liina,Tso Eugene Y K,Tucci Alessandra,Tüter Öz Şadiye Kübra,Ursini Matilde Valeria,Utsumi Takanori,Uzunhan Yurdagul,Vabres Pierre,Valencia-Ramos Juan,Van Den Rym Ana Maria,Vandernoot Isabelle,Velez-Santamaria Valentina,Zuniga Veliz Silvia Patricia,Vidigal Mateus C,Viel Sébastien,Vilain Cédric,Vilaire-Meunier Marie E,Villar-García Judit,Vincent Audrey,Vogt Guillaume,Voiriot Guillaume,Volokha Alla,Vuotto Fanny,Wauters Els,Wauters Joost,Wu Alan K L,Wu Tak-Chiu,Yahşi Aysun,Yesilbas Osman,Yildiz Mehmet,Young Barnaby E,Yükselmiş Ufuk,Zatz Mayana,Zecca Marco,Zuccaro Valentina,Jens Van Praet,Lambrecht Bart N.,Eva Van Braeckel,Cédric Bosteels,Levi Hoste,Eric Hoste,Bauters Fré,De Clercq Jozefien,Cathérine Heijmans,Hans Slabbynck,Leslie Naesens,Florkin Benoit,Boulanger Cécile,Vanderlinden Dimitri,Foti Giuseppe,Bellani Giacomo,Citerio Giuseppe,Contro Ernesto,Pesci Alberto,Valsecchi Maria Grazia,Cazzaniga Marina,Danielson Jeffrey J.,Dobbs Kerry,Kashyap Anuj,Ding Li,Dalgard Clifton L.,Sottini Alessandra,Quaresima Virginia,Quiros-Roldan Eugenia,Rossi Camillo,Bettini Laura Rachele,D’Angio’ Mariella,Beretta Ilaria,Montagna Daniela,Licari Amelia,Marseglia Gian Luigi,Batten Isabella,Reddy Conor,McElheron Matt,Noonan Claire,Connolly Emma,Fallon Aoife,Storgaard Merete,Jørgensen Sofie,Tolstrup Martin,Erikstrup Christian,Pedersen Ole Birger,Sørensen Erik,Mikkelsen Susan,Dinh Khoa Manh,Larsen Margit Anita Hørup,Paulsen Isabella Worlewenut,Von Stemann Jakob Hjorth,Hansen Morten Bagge,Ostrowski Sisse Rye,Townsend Liam,Cheallaigh Cliona Ni,Bergin Colm,Martin-Loeches Ignacio,Dunne Jean,Conlon Niall,Bourke Nollaig,O'Farrelly Cliona,Abel Laurent,Allavena Clotilde,Andrejak Claire,Angoulvant François,Azoulay Cecile,Bachelet Delphine,Bartoli Marie,Basmaci Romain,Behilill Sylvie,Beluze Marine,Benech Nicolas,Benkerrou Dehbia,Bhavsar Krishna,Bitker Laurent,Bouadma Lila,Bouscambert-Duchamp Maude,Paz Pauline Caraux,Cervantes-Gonzalez Minerva,Chair Anissa,Chirouze Catherine,Coelho Alexandra,Cordel 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Magalie,Bruneau Léa,Gérardin Patrick,Maillot Adrien,Payet Christine,Laviolle Bruno,Laine Fabrice,Paris Christophe,Desille-Dugast Mireille,Fouchard Julie,Malvy Denis,Nguyen Duc,Pistone Thierry,Perreau Pauline,Gissot Valérie,Le Goas Carole,Montagne Samatha,Richard Lucie,Chirouze Catherine,Bouiller Kévin,Desmarets Maxime,Meunier Alexandre,Lefévre Benjamin,Jeulin Hélène,Legrand Karine,Lomazzi Sandra,Tardy Bernard,Gagneux-Brunon Amandine,Bertholon Frédérique,Botelho-Nevers Elisabeth,Kouakam Christelle,Leturque Nicolas,Roufai Layidé,Amat Karine,Couffin-Cadiergues Sandrine,Espérou Hélène,Hendou Samia,van Agtmael Michiel,Algera Anne Geke,Appelman Brent,van Baarle Frank,Bax Diane,Beudel Martijn,Bogaard Harm Jan,Bomers Marije,Bonta Peter,Bos Lieuwe,Botta Michela,de Brabander Justin,de Bree Godelieve,de Bruin Sanne,Buis David T.P.,Bugiani Marianna,Bulle Esther,Chouchane Osoul,Cloherty Alex,Dijkstra Mirjam,Dongelmans Dave A.,Dujardin Romein W.G.,Elbers Paul,Fleuren Lucas,Geijtenbeek Suzanne Geerlings Theo,Girbes Armand,Goorhuis Bram,Grobusch Martin P.,Hafkamp Florianne,Hagens Laura,Hamann Jorg,Harris Vanessa,Hemke Robert,Hermans Sabine M.,Heunks Leo,Hollmann Markus,Horn Janneke,Hovius Joppe W.,de Jong Menno D.,Koning Rutger,Lim Endry H.T.,van Mourik Niels,Nellen Jeaninne,Nossent Esther J.,Paulus Frederique,Peters Edgar,Pina-Fuentes Dan A.I.,van der Poll Tom,Preckel Bennedikt,Prins Jan M.,Raasveld Jorinde,Reijnders Tom,de Rotte Maurits C.F.J.,Schinkel Michiel,Schultz Marcus J.,Schrauwen Femke A.P.,Schuurmans Alex,Schuurmans Jaap,Sigaloff Kim,Slim Marleen A.,Smeele Patrick,Smit Marry,Stijnis Cornelis S.,Stilma Willemke,Teunissen Charlotte,Thoral Patrick,Tsonas Anissa M,Tuinman Pieter R.,van der Valk Marc,Veelo Denise,Volleman Carolien,de Vries Heder,Vught Lonneke A.,van Vugt Michèle,Wouters Dorien,Zwinderman A. H (Koos,Brouwer Matthijs C.,Wiersinga W. Joost,Vlaar Alexander P.J.,van de Beek Diederik,Abel Laurent,Aiuti Alessandro,Al-Muhsen Saleh,Al-Mulla Fahd,Anderson Mark S.,Andreakos Evangelos,Arias Andrés A.,Feldman Hagit Baris,Belot Alexandre,Biggs Catherine M.,Bogunovic Dusan,Bolze Alexandre,Bondarenko Anastasiia,Bousfiha Ahmed A.,Brodin Petter,Bryceson Yenan,Bustamante Carlos D.,Butte Manish J.,Casari Giorgio,Chakravorty Samya,Christodoulou John,Condino-Neto Antonio,Constantinescu Stefan N.,Cooper Megan A.,Dalgard Clifton L.,Desai Murkesh,Drolet Beth A.,El Baghdadi Jamila,Espinosa-Padilla Sara,Fellay Jacques,Flores Carlos,Franco José Luis,Froidure Antoine,Gregersen Peter K.,Haerynck Filomeen,Hagin David,Halwani Rabih,Hammarström Lennart,Heath James R.,Henrickson Sarah E.,Hsieh Elena W.Y.,Husebye Eystein S.,Imai Kohsuke,Itan Yuval,Jarvis Erich D.,Karamitros Timokratis,Kisand Kai,Ku Cheng-Lung,Lau Yu-Lung,Ling Yun,Lucas Carrie L.,Maniatis Tom,Mansouri Davood,Maródi László,Meyts Isabelle,Milner Joshua D.,Mironska Kristina,Mogensen Trine H.,Morio Tomohiro,Ng Lisa F.P.,Notarangelo Luigi D.,Novelli Antonio,Novelli Giuseppe,O'Farrelly Cliona,Okada Satoshi,Ozcelik Tayfun,Pan-Hammarström Qiang,de Diego Rebeca Perez,Planas Anna M.,Prando Carolina,Pujol Aurora,Quintana-Murci Lluis,Renia Laurent,Resnick Igor,Rodríguez-Gallego Carlos,Sancho-Shimizu Vanessa,Sediva Anna,Seppänen Mikko R.J.,Shahrooei Mohammed,Shcherbina Anna,Slaby Ondrej,Snow Andrew L.,Soler-Palacín Pere,Spaan András N.,Tancevski Ivan,Tangye Stuart G.,Abou Tayoun Ahmad,Ramaswamy Sathishkumar,Turvey Stuart E,Uddin K M Furkan,Uddin Mohammed J.,van de Beek Diederik,Vinh Donald C.,von Bernuth Horst,Zatz Mayana,Zawadzki Pawel,Su Helen C.,Casanova Jean-Laurent,Nadif Rachel,Goldberg Marcel,Ozguler Anna,Henny Joseph,Lemonnier Sylvie,Coeuret-Pellicer Mireille,Le Got Stéphane,Zins Marie,Tzourio Christophe,Debette Stéphanie,Dufouil Carole,Soumaré Aïcha,Lachaize Morgane,Fievet Nathalie,Flaig Amandine,Martin Fernando,Bonneaudeau Brigitte,Cannet Dorothée,Gallian Pierre,Jeanne Michel,Perroquin Magali,Hamzeh-Cognasse Hind, , , , , , , , , , , , , , , , , ,

Affiliation:

1. Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163, Necker Hospital for Sick Children, Paris, France.

2. University of Paris, Imagine Institute, Paris, France.

3. St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, Rockefeller University, New York, NY, USA.

4. Laboratory of Virology and Infectious Disease, Rockefeller University, New York, NY, USA.

5. Department of Pediatrics, Graduate School of Biomedical and Health Sciences, Hiroshima University, Hiroshima, Japan.

6. Pediatric Infectious Diseases and Immunodeficiencies Unit, Hospital Universitari Vall d’Hebron, Vall d’Hebron Research Institute, Vall d’Hebron Barcelona Hospital Campus, Universitat Autònoma de Barcelona (UAB), Barcelona, Catalonia, Spain.

7. Institute of Biomedicine and Translational Medicine, University of Tartu, Tartu, Estonia.

8. Service de Médecine Intensive Réanimation, Hôpitaux Universitaires Henri Mondor, Assistance Publique-Hôpitaux de Paris (AP-HP), Paris, France.

9. Groupe de Recherche Clinique CARMAS, Faculté de santé de Créteil, Université Paris Est Créteil, 51 Avenue du Maréchal de Lattre de Tassigny, 94010 Créteil Cedex, France.

10. Avicenne Hospital, AP-HP, Bobigny, INSERM U1272, Hypoxia and Lung, Bobigny, France.

11. Sorbonne Université, Hôpital Pitié Salpêtrière, Médecine Intensive Réanimation, AP-HP, Paris, France.

12. INSERM UMRS 1166-iCAN, Institute of Cardiometabolism and Nutrition, Paris, France.

13. Internal Medicine Department, Lariboisière Hospital AP-HP, Paris University, Paris, France.

14. University of Lille, U1019-UMR9017, Center for Infection and Immunity of Lille, Lille, France.

15. CNRS, UMR9017, Lille, France.

16. INSERM U1019, Lille, France.

17. Institut Pasteur de Lille, Lille, France.

18. CHU de Lille, Pôle de Réanimation, Hôpital Roger Salengro Lille, Lille, France.

19. Etablissement Français Du Sang, La Plaine Saint-Denis, France.

20. UMR1098 RIGHT, INSERM, EFS, Université de Franche-Comté, Besançon, France.

21. SAINBIOSE, INSERM U1059, University of Lyon, Université Jean Monnet Saint-Etienne, Saint-Étienne, France.

22. Etablissement Français du Sang, Auvergne-Rhône-Alpes, Saint-Étienne, France.

23. Department of Internal Medicine, Infanta Leonor University Hospital, Madrid, Spain.

24. Hospices Civils de Lyon, Lyon, France.

25. International Center of Research in Infectiology, Lyon University, INSERM U1111, CNRS UMR 5308, ENS, UCBL, Lyon, France.

26. Joint Research Unit, Hospices Civils de Lyon-BioMérieux, Hospices Civils de Lyon, Lyon Sud Hospital, Pierre-Bénite, France.

27. National Referee Centre for Rheumatic, and Autoimmune and Systemic Diseases in Children (RAISE), Lyon, France.

28. Immunopathology Federation LIFE, Hospices Civils de Lyon, Lyon, France.

29. Intensive Care Unit, Grand Hôpital de l’Est Francilien Site de Marne-La-Vallée, Jossigny, France.

30. Institut Hospitalo-Universitaire Méditerranée Infection , Marseille, France.

31. Aix-Marseille Université, IRD, Assistance Publique Hôpitaux de Marseille (APHM), MEPHI, Marseille, France.

32. Service d’Evaluation Médicale, Hôpitaux Universitaires de Marseille APHM, Marseille, France.

33. Aix-Marseille University, School of Medicine, La Timone Medical Campus, EA 3279, CEReSS–Health Service Research and Quality of Life Center, Marseille, France.

34. Laboratory of Clinical Immunology and Microbiology, Division of Intramural Research, NIAID, National Institutes of Health (NIH), Bethesda, MD, USA.

35. Department of Pediatrics and Developmental Biology, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University (TMDU), Tokyo, Japan.

36. Department of Epidemiology, Infectious Disease Control and Prevention, Graduate School of Biomedical and Health Sciences, Hiroshima University, Hiroshima, Japan.

37. Hospital Universitari MútuaTerrassa; Fundació Docència i Recerca MutuaTerrassa, Terrasa; Universitat de Barcelona.

38. Paris Cardiovascular Research Center, PARCC, INSERM, Université de Paris, Paris, France.

39. Service d’Hématologie Biologique, Hôpital Lariboisière, AP-HP and EA3518, Institut Universitaire d’Hématologie-Hôpital Saint Louis, Université Paris Diderot, Paris, France.

40. Réanimation Médicale et Toxicologique, Hôpital Lariboisière (AP-HP), Université Paris-Diderot, INSERM Unité Mixte de Recherche Scientifique (UMRS) 1144, Paris, France.

41. Laboratory of Immunobiology, Center for Clinical, Experimental Surgery, and Translational Research, Biomedical Research Foundation of the Academy of Athens, 11527 Athens, Greece.

42. Service de Parasitologie-Mycologie, Groupe Hospitalier Pitié Salpêtrière, AP-HP, Paris, France.

43. Institute for Systems Biology, Seattle, WA, USA.

44. Primary Immunodeficiencies Group, Department of Microbiology and Parasitology, School of Medicine, University of Antioquia UdeA, Medellín, Colombia.

45. Center for Autoimmune Disease Research, School of Medicine and Health Sciences, Universidad del Rosario, Bogotá, Colombia.

46. Intensive Care Medicine, University Hospital of Gran Canaria Dr. Negrín, Canarian Health System, Las Palmas de Gran Canaria, Canary Islands, Spain.

47. CIBER de Enfermedades Respiratorias (CIBERES), Instituto de Salud Carlos III, Madrid, Spain.

48. CREA Laboratory, Diagnostic Department, ASST Spedali Civili di Brescia, Brescia, Italy.

49. Pediatric Department and Centro Tettamanti-European Reference Network PaedCan, EuroBloodNet, MetabERN, University of Milano Bicocca, Fondazione MBBM, Ospedale San Gerardo, Monza, Italy.

50. Department of Infectious Diseases, San Gerardo Hospital, University of Milano Bicocca, Monza, Italy.

51. Department of Pediatrics, Fondazione IRCCS Policlinico San Matteo, University of Pavia, Pavia, Italy.

52. NIAID Clinical Genomics Program, NIH, Bethesda, USA.

53. Department of Pharmacology and Molecular Therapeutics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA.

54. Department of Pediatrics, British Columbia Children’s Hospital, University of British Columbia, Vancouver, BC, Canada.

55. Primary Immunodeficiencies Group, University of Antioquia UdeA, Medellin, Colombia.

56. School of Microbiology, University of Antioquia UdeA, Medellin, Colombia.

57. Department of Nephrology and Transplantation, Necker University Hospital, APHP, Paris, France.

58. INEM, INSERM U1151–CNRS UMR 8253, Paris University, Paris, France.

59. Institute for Biomedical Research (IIBB), Spanish National Research Council (CSIC), Barcelona, Spain.

60. Institut d’Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Barcelona, Spain.

61. Department of Paediatric Immunology and Pulmonology, Center for Primary Immunodeficiency Ghent, Jeffrey Modell Diagnosis and Research Center, Ghent University Hospital, Ghent, Belgium.

62. Faculty of Medical Sciences, University “Goce Delchev,” Štip, Republic of Northern Macedonia.

63. Institute of public health of the Republic of North Macedonia, Skopje, Republic of Northern Macedonia.

64. Cancer Genetics and Prevention Program, University of California, San Francisco, San Francisco, CA, USA.

65. Department of Molecular Biology and Genetics, Bilkent University, Bilkent, Ankara, Turkey.

66. Meram Faculty of Medicine, Necmettin Erbakan University, Konya, Turkey.

67. Clinical Immunology Unit, Department of Pediatric Infectious Disease, CHU Ibn Rushd and LICIA, Laboratoire d’Immunologie Clinique, Inflammation et Allergie, Faculty of Medicine and Pharmacy, Hassan II University, Casablanca, Morocco.

68. Department of Immunology, CIC1408, GIMAP Centre International de Recherche en Infectiologie (CIRI) INSERM U1111, University Hospital of Saint-Étienne, Saint-Étienne, France.

69. Department of Biosciences and Nutrition, Karolinska Institutet, Stockholm, Sweden.

70. Université de Lille, INSERM, CHU de Lille, Institut Pasteur de Lille, U1011-EGID, F-59000 Lille, France.

71. Genetics Institute, Tel Aviv Sourasky Medical Center, Tel Aviv University, Tel Aviv, Israel.

72. Feinstein Institutes for Medical Research, Northwell Health, Manhasset, NY, USA.

73. Vita-Salute San Raffaele University, and Clinical Genomics, IRCCS Ospedale San Raffaele, Milan, Italy.

74. Diabetes Research Institute, IRCCS San Raffaele Scientific Institute, Milan, Italy.

75. Hematology and Bone Marrow Transplantation Unit, IRCCS San Raffaele Scientific Institute, Milano, Italy.

76. Department of Immunology, Institute of Biomedical Sciences, University of São Paulo, São Paulo, Brazil.

77. Fundación Rioja Salud, Centro de Investigación Biomédica de La Rioja, Logroño, Spain.

78. University of São Paulo, São Paulo, Brazil.

79. Department of Neurology, Amsterdam Neuroscience, Amsterdam, Netherlands.

80. Department of Internal Medicine II, Medical University of Innsbruck, Innsbruck, Austria.

81. Shupyk National Healthcare University of Ukraine, Kyiv, Ukraine.

82. Department of Children’s Diseases and Pediatric Surgery, I. Horbachevsky Ternopil National Medical University, Ternopil, Ukraine.

83. Department of Infection Control and Prevention, Medical Hospital, TMDU, Tokyo, Japan.

84. Intensive Care Medicine, Donostia University Hospital, Biodonostia Institute of Donostia, San Sebastián, Spain.

85. CIBERES, Instituto de Salud Carlos III, Madrid, Spain.

86. Garvan Institute of Medical Research, Sydney, Australia.

87. Sorbonne Université, INSERM U1136, Institut Pierre Louis d’Epidémiologie et de Santé Publique (iPLESP), AP-HP, Hôpital Pitié Salpêtrière, Service de Virologie, Paris, France.

88. St Vincent’s Clinical School, Faculty of Medicine and Health, UNSW Sydney, New South Wales, Australia.

89. Translational Immunology Laboratory, Institut Pasteur, Paris, France.

90. Human Evolutionary Genetics Unit, Institut Pasteur, CNRS UMR 2000, Paris, France.

91. Chair of Human Genomics and Evolution, Collège de France, Paris, France.

92. Department of Immunology, 2nd Faculty of Medicine, Charles University and University Hospital in Motol, Prague, Czech Republic.

93. Dmitry Rogachev National Medical Research Center of Pediatric Hematology, Oncology and Immunology, Moscow, Russia.

94. Department of Paediatrics and Adolescent Medicine, University of Hong Kong, Hong Kong, China.

95. Division of Geriatric Medicine, Tours University Medical Center, Tours, France.

96. INSERM U1259, MAVIVH, Université de Tours, Tours, France.

97. Service de Bactériologie, Virologie et Hygiène hospitalière, CHU de Tours, Tours, France.

98. Department of Microbiology, Universidad de La Sabana, Chía, Colombia.

99. Department of Critical Care Medicine, Clínica Universidad de La Sabana, Chía, Colombia.

100. Service de Biologie Médicale, CHI Robert Ballanger, Aulnay-sous-Bois, France.

101. Laboratoire d’Immunologie, Hospices Civils de Lyon, Hôpital Edouard Herriot, Lyon, France.

102. CIRI, INSERM U1111, CNRS, UMR5308, Ecole Normale Supérieure de Lyon, Université Claude Bernard Lyon 1, Lyon, France.

103. EA 7426, Pathophysiology of Injury-Induced Immunosuppression, Université Claude Bernard Lyon 1, Hospices Civils de Lyon, Hôpital Edouard Herriot-BioMérieux, Lyon, France.

104. Laboratory of Molecular Immunology, Rockefeller University, New York, NY, USA.

105. Howard Hughes Medical Institute, New York, NY, USA.

106. Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel.

107. Allergy and Clinical Immunology Unit, Department of Medicine, Tel Aviv Sourasky Medical Center, Tel Aviv, Israel.

108. Medical Intensive Care Unit, University Hospitals Leuven, Leuven, Belgium.

109. Laboratory of Inborn Errors of Immunity, Department of Microbiology, Immunology and Transplantation, KU Leuven, Leuven, Belgium.

110. Department of Pediatrics, Jeffrey Modell Diagnostic and Research Network Center, University Hospitals Leuven, Leuven, Belgium.

111. Department of Age-Related Healthcare, Tallaght University Hospital, Dublin, Ireland.

112. Department of Medical Gerontology, School of Medicine, Trinity College Dublin, Dublin, Ireland.

113. Sharjah Institute for Medical Research, College of Medicine, University of Sharjah, Sharjah, United Arab Emirates.

114. Sorbonne Université, INSERM, Centre d’Immunologie et des Maladies Infectieuses, (CIMI-Paris), Paris, France.

115. Cerba HealthCare, Issy-les-Moulineaux, France.

116. Department of Pediatrics, King Fahad Hospital of the University, Al Khobar, Saudi Arabia.

117. College of Medicine, Imam Abdulrahman Bin Faisal University, Dammam, Saudi Arabia.

118. Department of Clinical Laboratory, Hospital Universitari de Bellvitge, IDIBELL, Barcelona, Spain.

119. Department of Immunology, Hospital Universitari de Bellvitge, IDIBELL, Barcelona, Spain.

120. Department of Medicine, Division of Infectious Diseases, McGill University Health Centre, Montréal, QC, Canada.

121. Infectious Disease Susceptibility Program, Research Institute of the McGill University Health Centre, Montréal, QC, Canada.

122. Department of Clinical Immunology, Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark.

123. Faculdades Pequeno Príncipe, Instituto de Pesquisa Pelé Pequeno Príncipe, Curitiba, Brazil.

124. Department of Medical Microbiology, University Medical Center Utrecht, Utrecht, Netherlands.

125. Service de Médecine Interne, Hôpital universitaire Jean-Verdier AP-HP, Bondy, France.

126. INSERM U1138, Centre de Recherche des Cordeliers, Paris, France.

127. School of Life Sciences, École Polytechnique Fédérale de Lausanne, Lausanne, Switzerland.

128. Precision Medicine Unit, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland.

129. Swiss Institute of Bioinformatics, Lausanne, Switzerland.

130. Imagine Institute, Université de Paris, INSERM UMR 1163, Paris, France.

131. Yale Center for Genome Analysis, Yale School of Medicine, New Haven, CT, USA.

132. Department of Genetics, Yale University School of Medicine, New Haven, CT, USA.

133. Department of Neurosurgery, Yale University School of Medicine, New Haven, CT, USA.

134. Department of Medical Genetics, Acibadem University School of Medicine, Istanbul, Turkey.

135. Laboratory of Human Genetics and Genomics, Rockefeller University, New York, NY, USA.

136. Diabetes Center, University of California San Francisco, San Francisco, CA, USA.

137. Department of Hematology, Necker Hospital, AP-HP, Paris, France.

138. Neurometabolic Diseases Laboratory, IDIBELL, Hospital Duran i Reynals, CIBERER U759, and Catalan Institution of Research and Advanced Studies (ICREA), Barcelona, Spain.

139. Department of Infectious Diseases, Aarhus University Hospital, Denmark.

140. Department of Biomedicine, Aarhus University, Aarhus, Denmark.

141. ADMA Biologics Inc., Ramsey, NJ, USA.

142. University of Bordeaux, INSERM, Bordeaux Population Health Center, UMR1219, F-33000 Bordeaux, France.

143. Bordeaux University Hospital, Department of Neurology, Institute of Neurodegenerative Diseases, F-33000 Bordeaux, France.

144. IHU Méditerranée Infection, Unité des Virus Émergents, UVE: Aix-Marseille University, IRD 190, INSERM 1207, Marseille, France.

145. INSERM CIC 1425, Paris, France.

146. Université de Paris, IAME UMR-S 1137, INSERM, Paris, France.

147. AP-HP, Département Epidémiologie, Biostatistiques et Recherche Clinique, Hôpital Bichat, Paris, France.

148. AP-HP, Bichat Claude Bernard Hospital, Infectious and Tropical Diseases Department, Paris, France.

149. Université de Paris, Université Paris-Saclay, UVSQ, INSERM UMS11, Villejuif, France.

150. Immunology Division, Genetics Department, Hospital Universitari Vall d’Hebron, Vall d’Hebron Research Institute, Vall d’Hebron Barcelona Hospital Campus, UAB, Barcelona, Catalonia, Spain.

151. Département d’Immunologie, AP-HP, Hôpital Pitié-Salpétrière, Paris, France.

152. Department of Internal Medicine, Hospital Universitari de Bellvitge, IDIBELL, Barcelona, Spain.

153. IrsiCaixa AIDS Research Institute and Institute for Health Science Research Germans Trias i Pujol (IGTP), Badalona, Spain.

154. Infectious Diseases and Immunity, Center for Health and Social Care Research (CESS), Faculty of Medicine, University of Vic-Central University of Catalonia (UVic-UCC), Vic, Spain.

155. Catalan ICREA, Barcelona, Spain.

156. Service de Biologie Clinique and UMR-S 1176, Hôpital Foch, Suresnes, France.

157. Department of Immunology, University Hospital of Gran Canaria Dr. Negrin, Canarian Health System, Las Palmas de Gran Canaria, Spain.

158. Department of Clinical Sciences, Universidad Fernando Pessoa Canarias, Las Palmas de Gran Canaria, Spain.

159. Department of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.

Abstract

Autoantibodies neutralizing type I IFNs increase in prevalence over 60 years of age and underlie about 20% of all fatal COVID-19 cases.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

General Medicine,Immunology

Reference50 articles.

1. Assessing the age specificity of infection fatality rates for COVID-19: systematic review, meta-analysis, and public policy implications

2. Age-specific mortality and immunity patterns of SARS-CoV-2

3. Factors associated with COVID-19-related death using OpenSAFELY

4. Immune determinants of COVID-19 disease presentation and severity

5. Life-Threatening COVID-19: Defective Interferons Unleash Excessive Inflammation

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