IL-1β is an innate immune sensor of microbial proteolysis-Reference-Cited by-同舟云学术

IL-1β is an innate immune sensor of microbial proteolysis

Published:2016-08-05 Issue:2 Volume:1 Page:
ISSN:2470-9468
Container-title:Science Immunology
language:en
Short-container-title:Sci. Immunol.

Author:

LaRock Christopher N.¹,Todd Jordan¹,LaRock Doris L.¹,Olson Joshua¹,O’Donoghue Anthony J.²,Robertson Avril A. B.³,Cooper Matthew A.³,Hoffman Hal M.¹,Nizet Victor¹²

Affiliation:

1. Division of Host-Microbe Systems and Therapeutics, Department of Pediatrics, University of California (UC), San Diego, La Jolla, CA 92093, USA.

2. Skaggs School of Pharmacy and Pharmaceutical Sciences, UC San Diego, La Jolla, CA 92093, USA.

3. Institute for Molecular Bioscience, University of Queensland, Brisbane, Queensland 4072, Australia.

Abstract

A microbial protease directly activates IL-1β, resulting in an inflammasome-independent innate immune response.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

General Medicine,Immunology

Reference44 articles.

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5. IL-1β-driven neutrophilia preserves antibacterial defense in the absence of the kinase IKKβ

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