The transcription factor Bcl11b promotes both canonical and adaptive NK cell differentiation

Author:

Holmes Tim D.12ORCID,Pandey Ram Vinay2ORCID,Helm Eric Y.3ORCID,Schlums Heinrich2ORCID,Han Hongya2,Campbell Tessa M.2ORCID,Drashansky Theodore T.3ORCID,Chiang Samuel4,Wu Cheng-Ying5ORCID,Tao Christine3,Shoukier Moneef6ORCID,Tolosa Eva7ORCID,Von Hardenberg Sandra8ORCID,Sun Miao910ORCID,Klemann Christian11ORCID,Marsh Rebecca A.410,Lau Colleen M.12ORCID,Lin Yin13,Sun Joseph C.12ORCID,Månsson Robert14ORCID,Cichocki Frank5ORCID,Avram Dorina315ORCID,Bryceson Yenan T.12ORCID

Affiliation:

1. Broegelmann Research Laboratory, Department of Clinical Sciences, University of Bergen, N-5021 Bergen, Norway.

2. Centre for Hematology and Regenerative Medicine, Department of Medicine, Karolinska Institutet, Karolinska University Hospital Huddinge, S-14186 Stockholm, Sweden.

3. Department of Anatomy and Cell Biology, College of Medicine, University of Florida, Gainesville, FL 32610, USA.

4. Division of Bone Marrow Transplantation and Immune Deficiency, Cincinnati Children’s Hospital Medical Center, Cincinnati, OH 45229, USA.

5. Division of Hematology, Oncology and Transplantation, Department of Medicine, University of Minnesota Cancer Center, Minneapolis, MN 55455, USA.

6. Prenatal Medicine Munich, Munich, Germany.

7. Department of Immunology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.

8. Department of Human Genetics, Hannover Medical University, Hannover, Germany.

9. Division of Human Genetics, Cincinnati Children’s Hospital Medical Center College of Medicine, University of Cincinnati, Cincinnati, OH 45229, USA.

10. Department of Pediatrics, University of Cincinnati, Cincinnati, OH 45221, USA.

11. Department of Pediatric Pneumology, Allergy and Neonatology, Hannover Medical School, Hannover, Germany.

12. Immunology Program, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.

13. Baylor Institute for Immunology Research, Baylor Research Institute, Dallas, TX 75246, USA.

14. Centre for Hematology and Regenerative Medicine, Department of Laboratory Medicine, Karolinska Institutet, Karolinska University Hospital Huddinge, S-14186 Stockholm, Sweden.

15. Department of Immunology, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL 33612, USA.

Abstract

Epigenetic and functional analyses of human NK cells identify a role for Bcl11b in canonical and adaptive NK cell differentiation.

Funder

National Institutes of Health

ASCRS Research Foundation

FUNDING

Vetenskapsrådet

Swedish Foundation for Strategic Research

Kræftfonden

Knut och Alice Wallenbergs Stiftelse

Karolinska Institutet

Publisher

American Association for the Advancement of Science (AAAS)

Subject

General Medicine,Immunology

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