Integrated longitudinal immunophenotypic, transcriptional, and repertoire analyses delineate immune responses in patients with COVID-19-Reference-Cited by-同舟云学术

Integrated longitudinal immunophenotypic, transcriptional, and repertoire analyses delineate immune responses in patients with COVID-19

Published:2021-08-10 Issue:62 Volume:6 Page:
ISSN:2470-9468
Container-title:Science Immunology
language:en
Short-container-title:Sci. Immunol.

Author:

Notarbartolo Samuele¹^ORCID,Ranzani Valeria¹^ORCID,Bandera Alessandra²³⁴^ORCID,Gruarin Paola¹,Bevilacqua Valeria¹,Putignano Anna Rita¹⁵^ORCID,Gobbini Andrea¹⁶^ORCID,Galeota Eugenia¹,Manara Cristina¹^ORCID,Bombaci Mauro¹^ORCID,Pesce Elisa¹^ORCID,Zagato Elena¹⁵^ORCID,Favalli Andrea¹,Sarnicola Maria Lucia¹,Curti Serena¹,Crosti Mariacristina¹^ORCID,Martinovic Martina¹,Fabbris Tanya¹,Marini Federico⁷^ORCID,Donnici Lorena¹^ORCID,Lorenzo Mariangela¹,Mancino Marilena¹^ORCID,Ungaro Riccardo²,Lombardi Andrea²^ORCID,Mangioni Davide²^ORCID,Muscatello Antonio²,Aliberti Stefano³⁸^ORCID,Blasi Francesco³⁸^ORCID,De Feo Tullia⁹^ORCID,Prati Daniele¹⁰^ORCID,Manganaro Lara¹,Granucci Francesca¹⁶,Lanzavecchia Antonio¹^ORCID,Francesco Raffaele De¹¹¹^ORCID,Gori Andrea²³⁴,Grifantini Renata¹^ORCID,Abrignani Sergio¹⁵^ORCID

Affiliation:

1. INGM, Istituto Nazionale Genetica Molecolare “Romeo ed Enrica Invernizzi”, Milan, Italy.

2. Infectious Diseases Unit, Fondazione IRCCS Ca’ Granda Ospedale Maggiore Policlinico, Milan, Italy.

3. Department of Pathophysiology and Transplantation, Università degli Studi di Milano, Milan, Italy.

4. Centre for Multidisciplinary Research in Health Science (MACH), Università degli Studi di Milano, Milan, Italy.

5. Department of Clinical Sciences and Community Health, Università degli Studi di Milano, Milan, Italy.

6. Department of Biotechnology and Biosciences, University of Milano-Bicocca, Milan, Italy.

7. Institute of Medical Biostatistics, Epidemiology and Informatics (IMBEI), University Medical Center, Mainz, Germany.

8. Respiratory Unit and Cystic Fibrosis Adult Center, Fondazione IRCCS Ca’ Granda Ospedale Maggiore Policlinico, Milan, Italy.

9. Unità Operativa Complessa (UOC) Coordinamento Trapianti, Fondazione IRCCS Ca’ Granda-Ospedale Maggiore Policlinico, Milan, Italy.

10. Fondazione IRCCS Ca’ Granda Ospedale Maggiore Policlinico, Department of Transfusion Medicine and Hematology, Milan, Italy.

11. Department of Pharmacological and Biomolecular Sciences, Università degli Studi di Milano, Milan, Italy.

Abstract

Characterization of the immune responses to SARS-CoV-2 reveals a CD8 + T cell subset that likely establishes the memory to the virus.

Funder

Regione Lombardia

Fondazione Romeo ed Enrica Invernizzi

Ministrstvo za zdravje

Italian Ministry of Health

Intesa San Paolo “Fondo di beneficenza ed opere di carattere sociale e culturale”

Publisher

American Association for the Advancement of Science (AAAS)

Subject

General Medicine,Immunology

Reference92 articles.

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2. Presenting Characteristics, Comorbidities, and Outcomes Among 5700 Patients Hospitalized With COVID-19 in the New York City Area

3. Features of 20 133 UK patients in hospital with covid-19 using the ISARIC WHO Clinical Characterisation Protocol: prospective observational cohort study

4. Clinical and immunological features of severe and moderate coronavirus disease 2019

5. Elevated Calprotectin and Abnormal Myeloid Cell Subsets Discriminate Severe from Mild COVID-19

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