Platelets subvert T cell immunity against cancer via GARP-TGFβ axis-Reference-Cited by-同舟云学术

Platelets subvert T cell immunity against cancer via GARP-TGFβ axis

Published:2017-05-05 Issue:11 Volume:2 Page:
ISSN:2470-9468
Container-title:Science Immunology
language:en
Short-container-title:Sci. Immunol.

Author:

Rachidi Saleh¹²^ORCID,Metelli Alessandra¹²^ORCID,Riesenberg Brian¹²^ORCID,Wu Bill X.¹²,Nelson Michelle H.¹²^ORCID,Wallace Caroline¹²^ORCID,Paulos Chrystal M.¹²³,Rubinstein Mark P.¹²³^ORCID,Garrett-Mayer Elizabeth²⁴^ORCID,Hennig Mirko⁵,Bearden Daniel W.⁶,Yang Yi¹²^ORCID,Liu Bei¹²^ORCID,Li Zihai¹²⁷^ORCID

Affiliation:

1. Department of Microbiology and Immunology, Medical University of South Carolina, Charleston, SC 29425, USA.

2. Hollings Cancer Center, Medical University of South Carolina, Charleston, SC 29425, USA.

3. Department of Surgery, Medical University of South Carolina, Charleston, SC 29425, USA.

4. Department of Public Health Sciences, Medical University of South Carolina, Charleston, SC 29425, USA.

5. Department of Biochemistry and Molecular Biology, Medical University of South Carolina, Charleston, SC 29425, USA.

6. National Institutes of Standards and Technology, Hollings Marine Laboratory, Charleston, SC 29412, USA.

7. First Affiliated Hospital, Zhengzhou University School of Medicine, Zhengzhou 450052, Henan, China.

Abstract

T cell immunity against cancer in mice is enhanced with platelet-specific deletion of GARP and by platelet inhibitors.

Funder

National Institutes of Health

National Cancer Institute

Publisher

American Association for the Advancement of Science (AAAS)

Subject

General Medicine,Immunology

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