High-throughput peptide-MHC complex generation and kinetic screenings of TCRs with peptide-receptive HLA-A*02:01 molecules-Reference-Cited by-同舟云学术

High-throughput peptide-MHC complex generation and kinetic screenings of TCRs with peptide-receptive HLA-A*02:01 molecules

Published:2019-07-05 Issue:37 Volume:4 Page:
ISSN:2470-9468
Container-title:Science Immunology
language:en
Short-container-title:Sci. Immunol.

Author:

Moritz Andreas¹²^ORCID,Anjanappa Raghavendra³^ORCID,Wagner Claudia²^ORCID,Bunk Sebastian²,Hofmann Martin²^ORCID,Pszolla Gabriele²,Saikia Ankur³^ORCID,Garcia-Alai Maria⁴,Meijers Rob⁴^ORCID,Rammensee Hans-Georg¹^ORCID,Springer Sebastian³^ORCID,Maurer Dominik²^ORCID

Affiliation:

1. Department of Immunology, Institute for Cell Biology, University of Tübingen, Tübingen, Germany.

2. Immatics Biotechnologies GmbH, Tübingen, Germany.

3. Department of Life Sciences and Chemistry, Jacobs University, Bremen, Germany.

4. European Molecular Biology Laboratory (EMBL), Hamburg Outstation, Notkestrasse 85, D-22607 Hamburg, Germany.

Abstract

Functionally empty and peptide-receptive soluble HLA-A*02:01 enables high-throughput analysis of TCR binding to peptide-MHCs. See the related Research Article by Saini et al . in this issue.

Funder

Deutsche Forschungsgemeinschaft

iNEXT

Publisher

American Association for the Advancement of Science (AAAS)

Subject

General Medicine,Immunology

Reference41 articles.

1. Peptides Naturally Presented by MHC Class I Molecules

2. HLA-A2-peptide complexes: refolding and crystallization of molecules expressed in Escherichia coli and complexed with single antigenic peptides.

3. Phenotypic Analysis of Antigen-Specific T Lymphocytes

4. High-Throughput T-Cell Epitope Discovery Through MHC Peptide Exchange

5. T cell receptor interactions with syngeneic and allogeneic ligands: Affinity measurements and crystallization

Cited by 37 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. Preparation empty peptide-receptive MHC class I complex for large-scale detection through photolabile peptide ligands;International Journal of Biological Macromolecules;2024-09

2. The present and future of bispecific antibodies for cancer therapy;Nature Reviews Drug Discovery;2024-03-06

3. MediMer: a versatile do-it-yourself peptide-receptive MHC class I multimer platform for tumor neoantigen-specific T cell detection;Frontiers in Immunology;2024-01-04

4. Successes and challenges in clinical gene therapy;Gene Therapy;2023-11

5. The estimated annual financial impact of gene therapy in the United States;Gene Therapy;2023-11