Antigen-specific antibody Fc glycosylation enhances humoral immunity via the recruitment of complement

Author:

Lofano Giuseppe1ORCID,Gorman Matthew J.1,Yousif Ashraf S.12,Yu Wen-Han13ORCID,Fox Julie M.4ORCID,Dugast Anne-Sophie1,Ackerman Margaret E.5ORCID,Suscovich Todd J.1,Weiner Joshua5ORCID,Barouch Dan16ORCID,Streeck Hendrik7,Little Susan8ORCID,Smith Davey89,Richman Douglas89ORCID,Lauffenburger Douglas3ORCID,Walker Bruce D.11011ORCID,Diamond Michael S.4ORCID,Alter Galit1

Affiliation:

1. Ragon Institute of MGH, MIT and Harvard, Cambridge, MA 02139, USA.

2. Department of Immunology and Biotechnology, Tropical Medicine Research Institute, Khartoum, Sudan.

3. Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA 02142, USA.

4. Departments of Medicine, Molecular Microbiology, and Pathology & Immunology, Washington University School of Medicine, St. Louis, MO 63110, USA.

5. Thayer School of Engineering, Dartmouth College, Hanover, NH 03755, USA.

6. Center for Virology and Vaccine Research, Beth Israel Deaconess Medical Center, Boston, MA 02115, USA.

7. Institut für HIV Forschung, Universität Duisburg-Essen, Essen, Germany.

8. University of California, San Diego, San Diego, CA 92093, USA.

9. VA San Diego Healthcare System, San Diego, CA 92161, USA.

10. Institute for Medical Engineering and Science, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.

11. Howard Hughes Medical Institute, Chevy Chase, MD 20815, USA.

Abstract

HIV-specific antibody sialylation enhances humoral immunity via increased antigen deposition within B cell follicles in a complement-dependent manner.

Funder

Bill and Melinda Gates Foundation

Publisher

American Association for the Advancement of Science (AAAS)

Subject

General Medicine,Immunology

Cited by 80 articles. 订阅此论文施引文献 订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献

同舟云学术

1.学者识别学者识别

2.学术分析学术分析

3.人才评估人才评估

"同舟云学术"是以全球学者为主线,采集、加工和组织学术论文而形成的新型学术文献查询和分析系统,可以对全球学者进行文献检索和人才价值评估。用户可以通过关注某些学科领域的顶尖人物而持续追踪该领域的学科进展和研究前沿。经过近期的数据扩容,当前同舟云学术共收录了国内外主流学术期刊6万余种,收集的期刊论文及会议论文总量共计约1.5亿篇,并以每天添加12000余篇中外论文的速度递增。我们也可以为用户提供个性化、定制化的学者数据。欢迎来电咨询!咨询电话:010-8811{复制后删除}0370

www.globalauthorid.com

TOP

Copyright © 2019-2024 北京同舟云网络信息技术有限公司
京公网安备11010802033243号  京ICP备18003416号-3