Gab3 is required for IL-2– and IL-15–induced NK cell expansion and limits trophoblast invasion during pregnancy-Reference-Cited by-同舟云学术

Gab3 is required for IL-2– and IL-15–induced NK cell expansion and limits trophoblast invasion during pregnancy

Published:2019-08-02 Issue:38 Volume:4 Page:
ISSN:2470-9468
Container-title:Science Immunology
language:en
Short-container-title:Sci. Immunol.

Author:

Sliz Anna¹²³^ORCID,Locker Kathryn C. S.¹²³^ORCID,Lampe Kristin¹²^ORCID,Godarova Alzbeta⁴^ORCID,Plas David R.⁵,Janssen Edith M.⁶^ORCID,Jones Helen⁷⁸^ORCID,Herr Andrew B.¹²³^ORCID,Hoebe Kasper⁶^ORCID

Affiliation:

1. Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, OH 45220, USA.

2. Division of Immunobiology, Cincinnati Children’s Hospital Research Foundation, Cincinnati, OH 45229, USA.

3. Immunology Graduate Program, Cincinnati Children’s Hospital Medical Center and the University of Cincinnati College of Medicine, Cincinnati, OH 45220, USA.

4. Biomedical Informatics Graduate Program, University of Cincinnati College of Medicine, Cincinnati, OH 45220, USA.

5. Vontz Center for Molecular Studies, University of Cincinnati, Cincinnati, OH 45267, USA.

6. Janssen R&D, Spring House, PA 19002, USA.

7. Division of General Pediatric and Thoracic Surgery, Cincinnati Children’s Hospital Medical Center, Cincinnati, OH 45229, USA.

8. Department of Surgery, University of Cincinnati College of Medicine, Cincinnati, OH 45220, USA.

Abstract

NK cells require Gab3 for peripheral expansion, tumor eradication, and resistance to trophoblast invasion during pregnancy. See the related Focus by Colucci .

Funder

NIH/NIAID

NIH/NIDDK

Maren Foundation

Publisher

American Association for the Advancement of Science (AAAS)

Subject

General Medicine,Immunology

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