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Revisiting IL-2: Biology and therapeutic prospects

Published:2018-07-20 Issue:25 Volume:3 Page:
ISSN:2470-9468
Container-title:Science Immunology
language:en
Short-container-title:Sci. Immunol.

Author:

Abbas Abul K.¹^ORCID,Trotta Eleonora²,R. Simeonov Dimitre²³,Marson Alexander²³,Bluestone Jeffrey A.²^ORCID

Affiliation:

1. Department of Pathology, University of California, San Francisco, San Francisco, CA, USA.

2. Diabetes Center, University of California, San Francisco, San Francisco, CA, USA.

3. Department of Microbiology and Immunology, University of California, San Francisco, San Francisco, CA 94143, USA.

Abstract

Deeper insights into the biology of interleukin-2 and its receptors are leading to therapeutic strategies for selective T reg stimulation.

Funder

Pfizer

Publisher

American Association for the Advancement of Science (AAAS)

Subject

General Medicine,Immunology

Reference89 articles.

1. Structure and expression of a cloned cDNA for human interleukin-2;Taniguchi T.;Nature,1983

2. IL-2: The First Effective Immunotherapy for Human Cancer

3. Production and characterization of monoclonal antibodies to human interleukin 2: Strategy and tactics;Smith K. A.;J. Immunol.,1983

4. Interleukin 2 deficiency is a common feature of autoimmune mice;Dauphinée M. J.;J. Immunol.,1981

5. Decreased production of and response to interleukin-2 by cultured lymphocytes from patients with systemic lupus erythematosus;Alcocer-Varela J.;J. Clin. Invest.,1982

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