Natural killer cell immunotypes related to COVID-19 disease severity

Author:

Maucourant Christopher1ORCID,Filipovic Iva1ORCID,Ponzetta Andrea1ORCID,Aleman Soo23,Cornillet Martin1ORCID,Hertwig Laura1ORCID,Strunz Benedikt1,Lentini Antonio4ORCID,Reinius Björn4,Brownlie Demi1ORCID,Cuapio Angelica1,Ask Eivind Heggernes56ORCID,Hull Ryan M.7ORCID,Haroun-Izquierdo Alvaro1ORCID,Schaffer Marie1,Klingström Jonas1ORCID,Folkesson Elin28ORCID,Buggert Marcus1ORCID,Sandberg Johan K.1ORCID,Eriksson Lars I.910,Rooyackers Olav1011ORCID,Ljunggren Hans-Gustaf1,Malmberg Karl-Johan156,Michaëlsson Jakob1,Marquardt Nicole1ORCID,Hammer Quirin1ORCID,Strålin Kristoffer23ORCID,Björkström Niklas K.1ORCID,

Affiliation:

1. Center for Infectious Medicine, Department of Medicine Huddinge, Karolinska Institutet, Karolinska University Hospital, Stockholm, Sweden.

2. Department of Infectious Diseases, Karolinska University Hospital, Stockholm, Sweden.

3. Division of Infectious Diseases and Dermatology, Department of Medicine Huddinge, Karolinska Institutet, Stockholm, Sweden.

4. Department of Medical Biochemistry and Biophysics, Karolinska Institutet, Stockholm, Sweden.

5. Department of Cancer Immunology, Institute for Cancer Research, Oslo University Hospital, Oslo, Norway.

6. K.G. Jebsen Centre for Cancer Immunotherapy, Institute of Clinical Medicine, University of Oslo, Oslo, Norway.

7. SciLifeLab, Department of Microbiology, Tumor and Cell Biology, Karolinska Institutet, Stockholm, Sweden.

8. Division of Infectious Diseases, Department of Medicine, Solna, Karolinska Institutet, Stockholm, Sweden.

9. Department of Physiology and Pharmacology, Section for Anesthesiology and Intensive Care, Karolinska Institutet, Stockholm, Sweden.

10. Function Perioperative Medicine and Intensive Care, Karolinska University Hospital, Stockholm, Sweden.

11. Department of Clinical Science, Intervention, and Technology (CLINTEC), Division for Anesthesiology and Intensive Care, Karolinska Institutet, Stockholm, Sweden.

Abstract

The NK cell activation landscape in acute SARS-CoV-2 infection is associated with COVID-19 disease severity.

Funder

Swedish Foundation for Strategic Research

Karolinska Institutet

Knut och Alice Wallenbergs Stiftelse

Stockholms Läns Landsting

Vetenskapsrådet

Nordstjernan AB

Publisher

American Association for the Advancement of Science (AAAS)

Subject

General Medicine,Immunology

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