TET enzymes augment activation-induced deaminase (AID) expression via 5-hydroxymethylcytosine modifications at the Aicda superenhancer-Reference-Cited by-同舟云学术

TET enzymes augment activation-induced deaminase (AID) expression via 5-hydroxymethylcytosine modifications at the Aicda superenhancer

Published:2019-04-12 Issue:34 Volume:4 Page:
ISSN:2470-9468
Container-title:Science Immunology
language:en
Short-container-title:Sci. Immunol.

Author:

Lio Chan-Wang J.¹^ORCID,Shukla Vipul¹^ORCID,Samaniego-Castruita Daniela¹^ORCID,González-Avalos Edahi¹,Chakraborty Abhijit²,Yue Xiaojing¹,Schatz David G.³^ORCID,Ay Ferhat²^ORCID,Rao Anjana¹⁴⁵⁶

Affiliation:

1. Division of Signaling and Gene Expression, La Jolla Institute, San Diego, CA, USA.

2. Division of Vaccine Discovery, La Jolla Institute, San Diego, CA, USA.

3. Department of Immunobiology, Yale University School of Medicine, New Haven, CT, USA.

4. Sanford Consortium for Regenerative Medicine, San Diego, CA, USA.

5. Department of Pharmacology, University of California, San Diego, San Diego, CA, USA.

6. Moores Cancer Center, University of California, San Diego, San Diego, CA, USA.

Abstract

TET enzymes promote B cell responses by augmenting Aicda expression via DNA modification at cis elements in the Aicda locus.

Funder

National Institutes of Health

Leukemia and Lymphoma Society

Kyowa Hakko Kirin

University of California Institute for Mexico and the United States

Consejo Nacional de Ciencia y Tecnología

Publisher

American Association for the Advancement of Science (AAAS)

Subject

General Medicine,Immunology

Reference73 articles.

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3. Tet2 and Tet3 cooperate with B-lineage transcription factors to regulate DNA modification and chromatin accessibility

4. TET proteins in natural and induced differentiation;Scott-Browne J. P.;Curr. Opin. Genet. Dev.,2017

5. Tissue-specific DNA demethylation is required for proper B-cell differentiation and function;Orlanski S.;Proc. Natl. Acad. Sci. U.S.A.,2016

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