Clonal selection drives protective memory B cell responses in controlled human malaria infection-Reference-Cited by-同舟云学术

Clonal selection drives protective memory B cell responses in controlled human malaria infection

Published:2018-02-09 Issue:20 Volume:3 Page:
ISSN:2470-9468
Container-title:Science Immunology
language:en
Short-container-title:Sci. Immunol.

Author:

Murugan Rajagopal¹^ORCID,Buchauer Lisa²³⁴^ORCID,Triller Gianna¹^ORCID,Kreschel Cornelia⁵,Costa Giulia⁵^ORCID,Pidelaserra Martí Gemma¹⁴^ORCID,Imkeller Katharina¹⁴,Busse Christian E.¹^ORCID,Chakravarty Sumana⁶,Sim B. Kim Lee⁶^ORCID,Hoffman Stephen L.⁶,Levashina Elena A.⁵^ORCID,Kremsner Peter G.⁷,Mordmüller Benjamin⁷^ORCID,Höfer Thomas²³^ORCID,Wardemann Hedda¹^ORCID

Affiliation:

1. B Cell Immunology, German Cancer Research Center, Heidelberg, Germany.

2. Theoretical Systems Biology, German Cancer Research Center, Heidelberg, Germany.

3. BioQuant Center, University of Heidelberg, Heidelberg, Germany.

4. Faculty of Biosciences, University of Heidelberg, Heidelberg, Germany.

5. Vector Biology Unit, Max Planck Institute for Infection Biology, Berlin, Germany.

6. Sanaria Inc., Rockville, MD 20850, USA.

7. Institute of Tropical Medicine and German Center for Infection Research, University of Tübingen, Tübingen, Germany.

Abstract

The clonal selection of potent germline antibodies outpaces affinity maturation in human anti-PfCSP memory B cell responses.

Funder

National Institute of Allergy and Infectious Diseases

Deutsches Zentrum für Infektionsforschung

Deutsche Forschungsgemeinschaft

Bundesministerium für Bildung und Forschung

Publisher

American Association for the Advancement of Science (AAAS)

Subject

General Medicine,Immunology

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